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- Histone-modifying_enzymes abstract "The packaging of the eukaryotic genome into highly condensed chromatin makes it inaccessible to the factors required for gene transcription, DNA replication, recombination and repair. Eukaryotes have developed intricate mechanisms to overcome this repressive barrier imposed by the chromatin. The nucleosome is composed of an octamer of the four core histones (H3, H4, H2A, H2B) around which 147 base pairs of DNA are wrapped. Several distinct classes of enzyme can modify histones at multiple sites. The figure on the right enlists those histone-modifying enzymes whose specificity has been determined. There are at least eight distinct types of modifications found on histones (see the legend box on the top left of the figure). Enzymes have been identified for acetylation,methylation, demethylation, phosphorylation,ubiquitination, sumoylation,ADP-ribosylation,deimination, and proline isomerization. For a detailed example of histone modifications in transcription regulation see RNA polymerase control by chromatin structure and table Influence of modifications on gene expression in mammalian cells.".
- Histone-modifying_enzymes thumbnail NucleosomeKG.jpg?width=300.
- Histone-modifying_enzymes wikiPageID "12139474".
- Histone-modifying_enzymes wikiPageRevisionID "594311451".
- Histone-modifying_enzymes hasPhotoCollection Histone-modifying_enzymes.
- Histone-modifying_enzymes subject Category:Epigenetics.
- Histone-modifying_enzymes subject Category:Genetics.
- Histone-modifying_enzymes subject Category:Proteins.
- Histone-modifying_enzymes type Abstraction100002137.
- Histone-modifying_enzymes type Chemical114806838.
- Histone-modifying_enzymes type Compound114818238.
- Histone-modifying_enzymes type Macromolecule114944888.
- Histone-modifying_enzymes type Material114580897.
- Histone-modifying_enzymes type Matter100020827.
- Histone-modifying_enzymes type Molecule114682133.
- Histone-modifying_enzymes type OrganicCompound114727670.
- Histone-modifying_enzymes type Part113809207.
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- Histone-modifying_enzymes type Protein114728724.
- Histone-modifying_enzymes type Proteins.
- Histone-modifying_enzymes type Relation100031921.
- Histone-modifying_enzymes type Substance100019613.
- Histone-modifying_enzymes type Thing100002452.
- Histone-modifying_enzymes type Unit109465459.
- Histone-modifying_enzymes comment "The packaging of the eukaryotic genome into highly condensed chromatin makes it inaccessible to the factors required for gene transcription, DNA replication, recombination and repair. Eukaryotes have developed intricate mechanisms to overcome this repressive barrier imposed by the chromatin. The nucleosome is composed of an octamer of the four core histones (H3, H4, H2A, H2B) around which 147 base pairs of DNA are wrapped.".
- Histone-modifying_enzymes label "Enzimas modificadoras de histonas".
- Histone-modifying_enzymes label "Histone-modifying enzymes".
- Histone-modifying_enzymes sameAs Enzimas_modificadoras_de_histonas.
- Histone-modifying_enzymes sameAs m.02vr3x0.
- Histone-modifying_enzymes sameAs Q5773144.
- Histone-modifying_enzymes sameAs Q5773144.
- Histone-modifying_enzymes sameAs Histone-modifying_enzymes.
- Histone-modifying_enzymes wasDerivedFrom Histone-modifying_enzymes?oldid=594311451.
- Histone-modifying_enzymes depiction NucleosomeKG.jpg.
- Histone-modifying_enzymes isPrimaryTopicOf Histone-modifying_enzymes.