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- Histone_code abstract "The histone code is a hypothesis that the transcription of genetic information encoded in DNA is in part regulated by chemical modifications to histone proteins, primarily on their unstructured ends. Together with similar modifications such as DNA methylation it is part of the epigenetic code. Histones associate with DNA to form nucleosomes, which themselves bundle to form chromatin fibers, which in turn make up the more familiar chromosome. Histones are globular proteins with a flexible N-terminus (taken to be the tail) that protrudes from the nucleosome. Many of the histone tail modifications correlate very well to chromatin structure and both histone modification state and chromatin structure correlate well to gene expression levels. The critical concept of the histone code hypothesis is that the histone modifications serve to recruit other proteins by specific recognition of the modified histone via protein domains specialized for such purposes, rather than through simply stabilizing or destabilizing the interaction between histone and the underlying DNA. These recruited proteins then act to alter chromatin structure actively or to promote transcription.For details of gene expression regulation by histone modifications see table below.".
- Histone_code wikiPageExternalLink generegulation.info.
- Histone_code wikiPageExternalLink 1815.pdf.
- Histone_code wikiPageExternalLink histone_modification.html.
- Histone_code wikiPageExternalLink histonetable.pdf.
- Histone_code wikiPageID "5462098".
- Histone_code wikiPageRevisionID "599455117".
- Histone_code hasPhotoCollection Histone_code.
- Histone_code subject Category:Epigenetics.
- Histone_code comment "The histone code is a hypothesis that the transcription of genetic information encoded in DNA is in part regulated by chemical modifications to histone proteins, primarily on their unstructured ends. Together with similar modifications such as DNA methylation it is part of the epigenetic code. Histones associate with DNA to form nucleosomes, which themselves bundle to form chromatin fibers, which in turn make up the more familiar chromosome.".
- Histone_code label "Código de histonas".
- Histone_code label "Histone code".
- Histone_code label "Histonmodifikation".
- Histone_code sameAs Histonmodifikation.
- Histone_code sameAs Código_de_histonas.
- Histone_code sameAs m.0dmy1x.
- Histone_code sameAs Q910897.
- Histone_code sameAs Q910897.
- Histone_code wasDerivedFrom Histone_code?oldid=599455117.
- Histone_code isPrimaryTopicOf Histone_code.