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- IGFBP4 abstract "Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells.The protein itself does not prevent the formation of cancer. However it may reduce the growth of cancer and act as an apoptotic factor.".
- IGFBP4 entrezgene "3487".
- IGFBP4 wikiPageID "14138443".
- IGFBP4 wikiPageRevisionID "591768403".
- IGFBP4 hasPhotoCollection IGFBP4.
- IGFBP4 requireManualInspection "no".
- IGFBP4 summaryText "This gene is a member of the insulin-like growth factor binding protein family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.".
- IGFBP4 updateCitations "yes".
- IGFBP4 updatePage "yes".
- IGFBP4 updateProteinBox "yes".
- IGFBP4 updateSummary "yes".
- IGFBP4 type Biomolecule.
- IGFBP4 type Protein.
- IGFBP4 type BiologicalObject.
- IGFBP4 comment "Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms.".
- IGFBP4 label "IGFBP4".
- IGFBP4 sameAs m.03cvrmm.
- IGFBP4 sameAs Q5970978.
- IGFBP4 sameAs Q5970978.
- IGFBP4 wasDerivedFrom IGFBP4?oldid=591768403.
- IGFBP4 isPrimaryTopicOf IGFBP4.