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- Iclaprim abstract "Iclaprim (INN), codenamed AR-100 and RO-48-2622, is a diaminopyrimidine dihydrofolate reductase (DHFR)-inhibiting extended-spectrum antibiotic active against gram positive organisms being developed for the treatment of complicated skin and soft tissue infections caused by antibiotic-resistant bacteria. It is structurally related to trimethoprim. In Phase III clinical trials, intravenously-administered iclaprim was found to be as effective as and better tolerated than linezolid in people with skin and soft tissue infections, many caused by methicillin-resistant Staphylococcus aureus (MRSA). In vitro, iclaprim is highly active against MRSA, vancomycin-resistant Staphylococcus aureus (VRSA), strains of Streptococcus pneumoniae resistant to several common antibiotics, and some Gram-negative bacteria.A new drug application for iclaprim was filed with the U.S. Food and Drug Administration in March 2008, and a marketing authorisation application (MAA) was accepted by the European Medicines Agency on August 21, 2008. Phase II clinical trials are being conducted to assess whether iclaprim can be taken by mouth as well as intravenously and whether it is effective for the treatment of hospital-acquired pneumonia.Iclaprim has been granted fast track status by the FDA.".
- Iclaprim atcPrefix "J01".
- Iclaprim atcSuffix "EA03".
- Iclaprim casNumber "192314-93-5".
- Iclaprim fdaUniiCode "42445HUU0O".
- Iclaprim iupacName "(RS)-5-[(2- cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine".
- Iclaprim pubchem "213043".
- Iclaprim thumbnail Iclaprim2DACS.svg?width=300.
- Iclaprim wikiPageExternalLink sdarticle.pdf.
- Iclaprim wikiPageID "19014504".
- Iclaprim wikiPageRevisionID "604267937".
- Iclaprim atcPrefix "J01".
- Iclaprim atcSuffix "EA03".
- Iclaprim bioavailability "Good".
- Iclaprim c "19".
- Iclaprim casNumber "192314".
- Iclaprim chembl "134561".
- Iclaprim chemspiderid "184736".
- Iclaprim drugName "Iclaprim".
- Iclaprim h "22".
- Iclaprim hasPhotoCollection Iclaprim.
- Iclaprim imagename "1".
- Iclaprim inchi "1".
- Iclaprim inchikey "HWJPWWYTGBZDEG-UHFFFAOYAK".
- Iclaprim iupacName "-5".
- Iclaprim kegg "D08337".
- Iclaprim legalStatus "Investigational".
- Iclaprim molecularWeight "354.403".
- Iclaprim n "4".
- Iclaprim o "3".
- Iclaprim pubchem "213043".
- Iclaprim routesOfAdministration "Oral, intravenous".
- Iclaprim smiles "COC1=COC".
- Iclaprim stdinchi "1".
- Iclaprim stdinchikey "HWJPWWYTGBZDEG-UHFFFAOYSA-N".
- Iclaprim unii "42445".
- Iclaprim verifiedfields "changed".
- Iclaprim verifiedrevid "416967709".
- Iclaprim watchedfields "changed".
- Iclaprim width "250".
- Iclaprim subject Category:Aromatic_amines.
- Iclaprim subject Category:Bacterial_dihydrofolate_reductase_inhibitors.
- Iclaprim subject Category:Chromenes.
- Iclaprim subject Category:Cyclopropanes.
- Iclaprim subject Category:Phenol_ethers.
- Iclaprim subject Category:Pyrimidines.
- Iclaprim type Abstraction100002137.
- Iclaprim type AliphaticCompound114601294.
- Iclaprim type Amine114739004.
- Iclaprim type AromaticAmines.
- Iclaprim type Base114618253.
- Iclaprim type Chemical114806838.
- Iclaprim type Compound114818238.
- Iclaprim type Element114840755.
- Iclaprim type Material114580897.
- Iclaprim type Matter100020827.
- Iclaprim type MethaneSeries114951377.
- Iclaprim type OrganicCompound114727670.
- Iclaprim type Part113809207.
- Iclaprim type PhenolEthers.
- Iclaprim type PhysicalEntity100001930.
- Iclaprim type Pyrimidine114999913.
- Iclaprim type Pyrimidines.
- Iclaprim type Quintessence114847103.
- Iclaprim type Relation100031921.
- Iclaprim type Substance100019613.
- Iclaprim type Drug.
- Iclaprim type DrugProduct.
- Iclaprim type FunctionalSubstance.
- Iclaprim comment "Iclaprim (INN), codenamed AR-100 and RO-48-2622, is a diaminopyrimidine dihydrofolate reductase (DHFR)-inhibiting extended-spectrum antibiotic active against gram positive organisms being developed for the treatment of complicated skin and soft tissue infections caused by antibiotic-resistant bacteria. It is structurally related to trimethoprim.".
- Iclaprim label "Iclaprim".
- Iclaprim label "Iclaprim".
- Iclaprim sameAs Iclaprim.
- Iclaprim sameAs m.04jczz1.
- Iclaprim sameAs Q907480.
- Iclaprim sameAs Q907480.
- Iclaprim sameAs Iclaprim.
- Iclaprim wasDerivedFrom Iclaprim?oldid=604267937.
- Iclaprim depiction Iclaprim2DACS.svg.
- Iclaprim isPrimaryTopicOf Iclaprim.
- Iclaprim name "Iclaprim".