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- Idiotopes abstract "An idiotope is the unique set of antigenic determinants (epitopes) of the variable portion of an antibody. In some cases it can be the actual antigen-binding site, and in some cases it may comprise variable region sequences outside of the antigen-binding site on the antibody itself. Thus each antibody would have multiple idiotopes; and the set of these individual idiotopes is termed the idiotype of the antibody. Idiotopes contrast with allotopes, which are non-varying structures on the Fc receptor.If a separate antibody is produced that has specific binding capabilities to an idiotope of the previously described antibody, it is said to be an "anti-idiotypic antibody". If such is the case, the anti-idiotypic antibodies will be able to bind to the B lymphocyte receptor for the original antigen and inhibit the immune response to that antigen. This type of regulation was proposed by Niels Jerne in 1974. He termed it the "Network Hypothesis". This type of B lymphocyte regulation may be partially responsible for preventing an immune response from getting out of control, which would elicit damage to host tissue or even cause an autoimmune diseased state.Because of the resemblance of anti-idiotypic antibodies to the original antigen, vaccine studies have been performed. These types of vaccines are called "idiotypic vaccines". None are produced commercially to date.".
- Idiotopes wikiPageID "4295385".
- Idiotopes wikiPageRevisionID "383098379".
- Idiotopes hasPhotoCollection Idiotopes.
- Idiotopes subject Category:Antibodies.
- Idiotopes subject Category:Immune_system.
- Idiotopes type Abstraction100002137.
- Idiotopes type Antibodies.
- Idiotopes type Antibody115027189.
- Idiotopes type Chemical114806838.
- Idiotopes type Compound114818238.
- Idiotopes type Macromolecule114944888.
- Idiotopes type Material114580897.
- Idiotopes type Matter100020827.
- Idiotopes type Molecule114682133.
- Idiotopes type OrganicCompound114727670.
- Idiotopes type Part113809207.
- Idiotopes type PhysicalEntity100001930.
- Idiotopes type Protein114728724.
- Idiotopes type Relation100031921.
- Idiotopes type Substance100019613.
- Idiotopes type Thing100002452.
- Idiotopes type Unit109465459.
- Idiotopes comment "An idiotope is the unique set of antigenic determinants (epitopes) of the variable portion of an antibody. In some cases it can be the actual antigen-binding site, and in some cases it may comprise variable region sequences outside of the antigen-binding site on the antibody itself. Thus each antibody would have multiple idiotopes; and the set of these individual idiotopes is termed the idiotype of the antibody.".
- Idiotopes label "Idiotopes".
- Idiotopes sameAs m.0bvncq.
- Idiotopes sameAs Q5989022.
- Idiotopes sameAs Q5989022.
- Idiotopes sameAs Idiotopes.
- Idiotopes wasDerivedFrom Idiotopes?oldid=383098379.
- Idiotopes isPrimaryTopicOf Idiotopes.