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• Inclusion_body_myositis abstract "Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs. There are two types: sporadic inclusion body myositis (sIBM) and hereditary inclusion body myopathy (hIBM).In sporadic inclusion body myositis [MY-oh-sigh-tis] muscle, two processes, one autoimmune and the other degenerative, appear to occur in the muscle cells in parallel. The inflammation aspect is characterized by the cloning of T cells that appear to be driven by specific antigens to invade muscle fibers. The degeneration aspect is characterized by the appearance of holes in the muscle cell vacuoles, deposits of abnormal proteins within the cells and in filamentous inclusions (hence the name inclusion body myositis). sIBM is a rare yet increasingly prevalent disease, being the most common cause of inflammatory myopathy in the over 50s; the most recent research, done in Australia, indicates that the incidence of IBM varies and is different in different populations and different ethnic groups. The authors found that the current prevalence was 14.9 per million in the overall population, with a prevalence of 51.3 per million population in people over 50 years of age. As seen in these numbers, sIBM is an age-related disease – its incidence increases with age and symptoms usually begin after 50 years of age. It is the most common acquired muscle disorder seen in people over 50, although about 20% of cases display symptoms before the age of 50. Weakness comes on slowly (over months or years) and progresses steadily and usually leads to severe weakness and wasting of arm and leg muscles. It is slightly more common in men than women. Patients may become unable to perform daily living activities and most require assistive devices within 5 to 10 years of symptom onset. sIBM is not considered a fatal disorder – barring complications, all things being equal, sIBM will not kill (but the risk of serious injury due to falls is increased). One common and potentially fatal complication is dysphagia. There is no effective treatment for the disease.".
• Inclusion_body_myositis diseasesdb "30691".
• Inclusion_body_myositis emedicineSubject "neuro".
• Inclusion_body_myositis emedicineTopic "422".
• Inclusion_body_myositis icd10 "M60.8".
• Inclusion_body_myositis icd9 "359.71".
• Inclusion_body_myositis meshId "D018979".
• Inclusion_body_myositis omim "147421".
• Inclusion_body_myositis wikiPageExternalLink www.ibmmyositis.com.
• Inclusion_body_myositis wikiPageExternalLink ?page_id=1107&group_id=8.
• Inclusion_body_myositis wikiPageExternalLink inclusion-body_myositis.cfm.
• Inclusion_body_myositis wikiPageExternalLink NBK1262.
• Inclusion_body_myositis wikiPageID "15538".
• Inclusion_body_myositis wikiPageRevisionID "605213974".
• Inclusion_body_myositis diseasesdb "30691".
• Inclusion_body_myositis emedicinesubj "neuro".
• Inclusion_body_myositis emedicinetopic "422".
• Inclusion_body_myositis genereviewsname "Inclusion Body Myopathy 2".
• Inclusion_body_myositis genereviewsnbk "NBK1262".
• Inclusion_body_myositis hasPhotoCollection Inclusion_body_myositis.
• Inclusion_body_myositis icd "359.71".
• Inclusion_body_myositis icd "M60.8".
• Inclusion_body_myositis meshid "D018979".
• Inclusion_body_myositis name "Inclusion body myositis".
• Inclusion_body_myositis omim "147421".
• Inclusion_body_myositis wordnet_type synset-disease-noun-1.
• Inclusion_body_myositis subject Category:Disorders_of_muscles.
• Inclusion_body_myositis subject Category:Inflammations.
• Inclusion_body_myositis subject Category:Systemic_connective_tissue_disorders.
• Inclusion_body_myositis type Disease.
• Inclusion_body_myositis type AilmentCondition.
• Inclusion_body_myositis type Situation.
• Inclusion_body_myositis comment "Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs. There are two types: sporadic inclusion body myositis (sIBM) and hereditary inclusion body myopathy (hIBM).In sporadic inclusion body myositis [MY-oh-sigh-tis] muscle, two processes, one autoimmune and the other degenerative, appear to occur in the muscle cells in parallel.".
• Inclusion_body_myositis label "Inclusion body myositis".
• Inclusion_body_myositis label "Miosite da corpi inclusi".
• Inclusion_body_myositis label "Miosite por corpúsculos de inclusão".
• Inclusion_body_myositis label "Sporadische Einschlusskörpermyositis".
• Inclusion_body_myositis label "封入体筋炎".
• Inclusion_body_myositis sameAs Sporadische_Einschlusskörpermyositis.
• Inclusion_body_myositis sameAs Miosite_da_corpi_inclusi.
• Inclusion_body_myositis sameAs 封入体筋炎.
• Inclusion_body_myositis sameAs Miosite_por_corpúsculos_de_inclusão.
• Inclusion_body_myositis sameAs m.03_1n.
• Inclusion_body_myositis sameAs Q1848471.
• Inclusion_body_myositis sameAs Q1848471.
• Inclusion_body_myositis wasDerivedFrom Inclusion_body_myositis?oldid=605213974.
• Inclusion_body_myositis isPrimaryTopicOf Inclusion_body_myositis.
• Inclusion_body_myositis name "Inclusion body myositis".