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- Incretin abstract "Incretins are a group of gastrointestinal hormones that stimulate a decrease in blood glucose levels. Incretins do so by causing an increase in the amount of insulin released from the beta cells of the islets of Langerhans after eating, before blood glucose levels become elevated. They also slow the rate of absorption of nutrients into the blood stream by reducing gastric emptying and may directly reduce food intake. As expected, they also inhibit glucagon release from the alpha cells of the Islets of Langerhans. The two main candidate molecules that fulfill criteria for an incretin are glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (also known as: glucose-dependent insulinotropic polypeptide or GIP). Both GLP-1 and GIP are rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1 (7-36) amide is not very useful for treatment of type 2 diabetes mellitus, since it must be administered by continuous subcutaneous infusion. Several long-lasting analogs having insulinotropic activity have been developed, and three, exenatide (Byetta) and liraglutide (Victoza), plus exenatide extended-release (Bydureon), have been approved for use in the U.S. The main disadvantage of these GLP-1 analogs is they must be administered by subcutaneous injection.Another approach is to inhibit the enzyme that inactivates GLP-1 and GIP, DPP-4. Several DPP-4 inhibitors that can be taken orally as a tablet have been developed.".
- Incretin thumbnail Incretins_and_DPP_4_inhibitors.svg?width=300.
- Incretin wikiPageExternalLink 194.long.
- Incretin wikiPageExternalLink www.glucagon.com.
- Incretin wikiPageID "1549790".
- Incretin wikiPageRevisionID "592461930".
- Incretin hasPhotoCollection Incretin.
- Incretin subject Category:Gastric_hormones.
- Incretin subject Category:Intestinal_hormones.
- Incretin subject Category:Peptide_hormones.
- Incretin type Abstraction100002137.
- Incretin type BodySubstance105263850.
- Incretin type GastricHormones.
- Incretin type Hormone105407119.
- Incretin type IntestinalHormones.
- Incretin type LiquidBodySubstance105397468.
- Incretin type Matter100020827.
- Incretin type Part113809207.
- Incretin type PeptideHormones.
- Incretin type PhysicalEntity100001930.
- Incretin type Relation100031921.
- Incretin type Secretion105404728.
- Incretin type Substance100019613.
- Incretin comment "Incretins are a group of gastrointestinal hormones that stimulate a decrease in blood glucose levels. Incretins do so by causing an increase in the amount of insulin released from the beta cells of the islets of Langerhans after eating, before blood glucose levels become elevated. They also slow the rate of absorption of nutrients into the blood stream by reducing gastric emptying and may directly reduce food intake.".
- Incretin label "Incretin".
- Incretin label "Incretina".
- Incretin label "Incretina".
- Incretin label "Incretine".
- Incretin label "Incretine".
- Incretin label "Incrétine".
- Incretin label "Inkretin-Effekt".
- Incretin label "Inkretyny".
- Incretin label "インクレチン".
- Incretin sameAs Inkretin.
- Incretin sameAs Inkretin-Effekt.
- Incretin sameAs Incretina.
- Incretin sameAs Incrétine.
- Incretin sameAs Inkretin.
- Incretin sameAs Incretine.
- Incretin sameAs インクレチン.
- Incretin sameAs Incretine.
- Incretin sameAs Inkretyny.
- Incretin sameAs Incretina.
- Incretin sameAs m.059l_v.
- Incretin sameAs Q1420402.
- Incretin sameAs Q1420402.
- Incretin sameAs Incretin.
- Incretin wasDerivedFrom Incretin?oldid=592461930.
- Incretin depiction Incretins_and_DPP_4_inhibitors.svg.
- Incretin isPrimaryTopicOf Incretin.
