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- Indirect_DNA_damage abstract "Indirect DNA damage occurs when a UV-photon is absorbed in the human skin by a chromophore that does not have the ability to convert the energy into harmless heat very quickly. Molecules that do not have this ability have a long-lived excited state. This long lifetime leads to a high probability for reactions with other molecules - so-called bimolecular reactions. Melanin and DNA have extremely short excited state lifetimes in the range of a few femtoseconds (10−15s). The excited state lifetime of these substances is 1,000 to 1,000,000 times longer than the lifetime of melanin, and therefore they may cause damage to living cells that come in contact with them.The molecule that originally absorbs the UV-photon is called a "chromophore". Bimolecular reactions can occur either between the excited chromophore and DNA or between the excited chromophore and another species, to produce free radicals and Reactive Oxygen Species. These reactive chemical species can reach DNA by diffusion and the bimolecular reaction damages the DNA (oxidative stress). It is important to note that indirect DNA damage does not result in any warning signal or pain in the human body.The bimolecular reactions that cause the indirect DNA damage are illustrated in the figure: 1O2 is reactive harmful singlet oxygen:".
- Indirect_DNA_damage thumbnail Indirect_DNA_damage.png?width=300.
- Indirect_DNA_damage wikiPageID "15737471".
- Indirect_DNA_damage wikiPageRevisionID "560466208".
- Indirect_DNA_damage hasPhotoCollection Indirect_DNA_damage.
- Indirect_DNA_damage subject Category:Photochemistry.
- Indirect_DNA_damage subject Category:Skin_conditions_resulting_from_physical_factors.
- Indirect_DNA_damage subject Category:Sun_tanning.
- Indirect_DNA_damage type Abstraction100002137.
- Indirect_DNA_damage type Attribute100024264.
- Indirect_DNA_damage type Condition113920835.
- Indirect_DNA_damage type SkinConditionsResultingFromPhysicalFactors.
- Indirect_DNA_damage type State100024720.
- Indirect_DNA_damage comment "Indirect DNA damage occurs when a UV-photon is absorbed in the human skin by a chromophore that does not have the ability to convert the energy into harmless heat very quickly. Molecules that do not have this ability have a long-lived excited state. This long lifetime leads to a high probability for reactions with other molecules - so-called bimolecular reactions. Melanin and DNA have extremely short excited state lifetimes in the range of a few femtoseconds (10−15s).".
- Indirect_DNA_damage label "Indirect DNA damage".
- Indirect_DNA_damage label "Первичные радиобиологические процессы".
- Indirect_DNA_damage sameAs m.03nrrpm.
- Indirect_DNA_damage sameAs Q1967197.
- Indirect_DNA_damage sameAs Q1967197.
- Indirect_DNA_damage sameAs Indirect_DNA_damage.
- Indirect_DNA_damage wasDerivedFrom Indirect_DNA_damage?oldid=560466208.
- Indirect_DNA_damage depiction Indirect_DNA_damage.png.
- Indirect_DNA_damage isPrimaryTopicOf Indirect_DNA_damage.
