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- Integrin_alpha_M abstract "Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins.αMβ2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b). The ITGAM (alpha) subunit of integrin αMβ2 is directly involved in causing the adhesion and spreading of cells but cannot mediate cellular migration without the presence of the β2 (CD18) subunit.In genomewide association studies, single nucleotide polymorphisms in ITGAM had the strongest association with systemic lupus erythematosus, with an odds ratio of 1.65 for the T allele of rs9888739 and lupus.".
- Integrin_alpha_M entrezgene "3684".
- Integrin_alpha_M wikiPageExternalLink report.cgi?report=orth_overview&gene_id=3684.
- Integrin_alpha_M wikiPageExternalLink index.shtml.
- Integrin_alpha_M wikiPageExternalLink humancdchart.htm.
- Integrin_alpha_M wikiPageExternalLink mousecdchart.htm.
- Integrin_alpha_M wikiPageID "5990252".
- Integrin_alpha_M wikiPageRevisionID "544463170".
- Integrin_alpha_M hasPhotoCollection Integrin_alpha_M.
- Integrin_alpha_M requireManualInspection "no".
- Integrin_alpha_M updateCitations "yes".
- Integrin_alpha_M updatePage "yes".
- Integrin_alpha_M updateProteinBox "yes".
- Integrin_alpha_M updateSummary "no".
- Integrin_alpha_M subject Category:Proteins.
- Integrin_alpha_M type Abstraction100002137.
- Integrin_alpha_M type Chemical114806838.
- Integrin_alpha_M type Compound114818238.
- Integrin_alpha_M type Macromolecule114944888.
- Integrin_alpha_M type Material114580897.
- Integrin_alpha_M type Matter100020827.
- Integrin_alpha_M type Molecule114682133.
- Integrin_alpha_M type OrganicCompound114727670.
- Integrin_alpha_M type Part113809207.
- Integrin_alpha_M type PhysicalEntity100001930.
- Integrin_alpha_M type Protein114728724.
- Integrin_alpha_M type Proteins.
- Integrin_alpha_M type Relation100031921.
- Integrin_alpha_M type Substance100019613.
- Integrin_alpha_M type Thing100002452.
- Integrin_alpha_M type Unit109465459.
- Integrin_alpha_M type Biomolecule.
- Integrin_alpha_M type Protein.
- Integrin_alpha_M type BiologicalObject.
- Integrin_alpha_M comment "Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B).".
- Integrin_alpha_M label "Integrin alpha M".
- Integrin_alpha_M label "Integrina alfa M".
- Integrin_alpha_M label "Integrina alfa M".
- Integrin_alpha_M label "Интегрин альфа-M".
- Integrin_alpha_M sameAs Integrina_alfa_M.
- Integrin_alpha_M sameAs Integrina_alfa_M.
- Integrin_alpha_M sameAs CD1B.
- Integrin_alpha_M sameAs m.0fjg2s.
- Integrin_alpha_M sameAs Q3799301.
- Integrin_alpha_M sameAs Q3799301.
- Integrin_alpha_M sameAs Integrin_alpha_M.
- Integrin_alpha_M wasDerivedFrom Integrin_alpha_M?oldid=544463170.
- Integrin_alpha_M isPrimaryTopicOf Integrin_alpha_M.