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- Iopanoic_acid abstract "Iopanoic acid is an iodine-containing radiocontrast medium used in cholecystography. Both iopanoic acid and ipodate sodium are potent inhibitors of thyroid hormone release from thyroid gland, as well as of peripheral conversion of thyroxine (T4) to triiodothyronine (T3). These compounds inhibit 5'deiodinase (5'DID-1 and 5'DID-2) enzymes, which catalyse T4-T3 conversion in the thyroid cell, liver, kidney, skeletal muscle, heart, brain, pituitary. This accounts for the dramatic improvement in both subjective and objective symptoms of hyperthyroidism, particularly when they are used as an adjunctive therapy with thioamides (propylthiouracil, carbimazole). These are less toxic, as iodine is covalently bound in these compounds. They can be used in the treatment of patients with severe thyrotoxicosis (thyroid storm) and significant morbidity (e.g., myocardial infarction, or stroke) for rapid control of elevated plasma triiodothyronine concentrations. The use of iopanoic acid for treatment of thyrotoxicosis has been discontinued in the United States.In addition to inhibiting deiodinase enzymes, iopanoic acid is also a substrate of type 1 deiodinase. Iopanoic acid underwent monodeiodination in the presence of type 1 deiodinase in a microsomal mouse liver preparation.".
- Iopanoic_acid atcPrefix "V08".
- Iopanoic_acid atcSuffix "AC06".
- Iopanoic_acid casNumber "96-83-3".
- Iopanoic_acid fdaUniiCode "FE9794P71J".
- Iopanoic_acid iupacName "(RS)-2-[(3-Amino-2,4,6-triiodophenyl)methyl]butanoic acid".
- Iopanoic_acid pubchem "3735".
- Iopanoic_acid thumbnail Iopanoic_acid.png?width=300.
- Iopanoic_acid wikiPageID "20362170".
- Iopanoic_acid wikiPageRevisionID "545502152".
- Iopanoic_acid atcPrefix "V08".
- Iopanoic_acid atcSuffix "AC06".
- Iopanoic_acid c "11".
- Iopanoic_acid casNumber "96".
- Iopanoic_acid chembl "867".
- Iopanoic_acid h "12".
- Iopanoic_acid hasPhotoCollection Iopanoic_acid.
- Iopanoic_acid i "3".
- Iopanoic_acid iupacName "-2".
- Iopanoic_acid kegg "D01014".
- Iopanoic_acid molecularWeight "570.93".
- Iopanoic_acid n "1".
- Iopanoic_acid o "2".
- Iopanoic_acid pubchem "3735".
- Iopanoic_acid unii "FE9794P71J".
- Iopanoic_acid subject Category:Organoiodides.
- Iopanoic_acid subject Category:Radiocontrast_agents.
- Iopanoic_acid type Agent109190918.
- Iopanoic_acid type CausalAgent100007347.
- Iopanoic_acid type PhysicalEntity100001930.
- Iopanoic_acid type RadiocontrastAgents.
- Iopanoic_acid type Drug.
- Iopanoic_acid type DrugProduct.
- Iopanoic_acid type FunctionalSubstance.
- Iopanoic_acid comment "Iopanoic acid is an iodine-containing radiocontrast medium used in cholecystography. Both iopanoic acid and ipodate sodium are potent inhibitors of thyroid hormone release from thyroid gland, as well as of peripheral conversion of thyroxine (T4) to triiodothyronine (T3). These compounds inhibit 5'deiodinase (5'DID-1 and 5'DID-2) enzymes, which catalyse T4-T3 conversion in the thyroid cell, liver, kidney, skeletal muscle, heart, brain, pituitary.".
- Iopanoic_acid label "Iopanoic acid".
- Iopanoic_acid label "Iopansäure".
- Iopanoic_acid sameAs Iopansäure.
- Iopanoic_acid sameAs m.04zv_db.
- Iopanoic_acid sameAs Q1672108.
- Iopanoic_acid sameAs Q1672108.
- Iopanoic_acid sameAs Iopanoic_acid.
- Iopanoic_acid wasDerivedFrom Iopanoic_acid?oldid=545502152.
- Iopanoic_acid depiction Iopanoic_acid.png.
- Iopanoic_acid isPrimaryTopicOf Iopanoic_acid.