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- Iron_dependent_repressor abstract "In molecular biology, the iron dependent repressors are a family of bacterial and archaeal transcriptional repressors.At their N-terminus they contain a dtxR-type HTH domain. This is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 65 amino acids present in metalloregulators of the dtxR/mntR family. The domain is named after Corynebacterium diphtheriae dtxR, an iron-specific diphtheria toxin repressor, and Bacillus subtilis mntR, a manganese transport regulator. Iron-responsive metalloregulators such as dtxR and ideR occur in Gram-positive bacteria of the high GC branch, while manganese-responsive metalloregulators like mntR are described in diverse genera of Gram-positive and Gram-negative bacteria and also in Archaea. The metalloregulators like dtxR/mntR contain the DNA-binding dtxR-type HTHdomain usually in the N-terminal part. The C-terminal part contains a dimerisation domain with two metal-binding sites, although the primary metal-binding site is less conserved in the Mn(II)-regulators. Fe(II)-regulated proteins contain an SH3-like domain as a C-terminal extension, which is absent in Mn(II)-regulated mntR.Metal-ion dependent regulators orchestrate the virulence of several important human pathogens. The dtxR protein regulates the expression of diphtheria toxin in response to environmental iron concentrations. Furthermore, dtxR and ideR control iron uptake. Homeostasis of manganese, which is an essential nutrient, is regulated by mntR. A typical dtxR-type metalloregulator binds two divalent metal effectors per monomer, upon which allosteric changes occur that moderate binding to the cognate DNA operators. Iron-bound dtxR homodimers bind to an interrupted palindrome of 19 bp, protecting a sequence of ~30 bp. The crystal structures of iron-regulated and manganese-regulated repressors show that the DNA binding domain contains three alpha-helices and a pair of antiparallel beta-strands. Helices 2 and 3 comprise the helix-turn-helix motif and the beta-strands are called the wing. This wHTH topology is similar to the lysR-type HTH. Most dtxR-type metalloregulators bind as dimers to the DNA major groove.Several proteins are known to contain a dtxR-type HTH domain. These include: Corynebacterium diphtheriae dtxR, a diphtheria toxin repressor, which regulates the expression of the high-affinity iron uptake system, other iron-sensitive genes, and the bacteriophage tox gene. Metal-bound dtxR represses transcription by binding the tox operator; if iron is limiting, conformational changes of the wHTH disrupt DNA-binding and the diphtheria toxin is produced. Mycobacterium tuberculosis ideR, an iron-dependent regulator that is essential for this pathogen. The regulator represses genes for iron acquisition and activates iron storage genes, and is a positive regulator of oxidative stress responses. Bacillus subtilis mntR, a manganese transport regulator, binds Mn2+ as an effector and is a transcriptional repressor of transporters for the import of manganese. Treponema pallidum troR, a metal-dependent transcriptional repressor. Archaeoglobus fulgidus MDR1 (troR), a metal-dependent transcriptional repressor, which negatively regulates its own transcription.".
- Iron_dependent_repressor symbol "Fe_dep_repr_C".
- Iron_dependent_repressor symbol "Fe_dep_repress".
- Iron_dependent_repressor thumbnail PDB_1u8r_EBI.jpg?width=300.
- Iron_dependent_repressor wikiPageID "32752072".
- Iron_dependent_repressor wikiPageRevisionID "591820414".
- Iron_dependent_repressor caption "crystal structure of an ider-dna complex reveals a conformational change in activated ider for base-specific interactions".
- Iron_dependent_repressor caption "the structure of apo-mntr from bacillus subtilis, selenomethionine derivative".
- Iron_dependent_repressor hasPhotoCollection Iron_dependent_repressor.
- Iron_dependent_repressor interpro "IPR001367".
- Iron_dependent_repressor interpro "IPR022687".
- Iron_dependent_repressor name "Iron dependent repressor, N-terminal DNA binding domain".
- Iron_dependent_repressor name "Iron dependent repressor, metal binding and dimerisation domain".
- Iron_dependent_repressor pfam "PF01325".
- Iron_dependent_repressor pfam "PF02742".
- Iron_dependent_repressor pfamClan "CL0123".
- Iron_dependent_repressor scop "2".
- Iron_dependent_repressor symbol "Fe_dep_repr_C".
- Iron_dependent_repressor symbol "Fe_dep_repress".
- Iron_dependent_repressor subject Category:Protein_domains.
- Iron_dependent_repressor type Abstraction100002137.
- Iron_dependent_repressor type Attribute100024264.
- Iron_dependent_repressor type Environment113934596.
- Iron_dependent_repressor type ProteinDomains.
- Iron_dependent_repressor type Situation113927383.
- Iron_dependent_repressor type Sphere114514039.
- Iron_dependent_repressor type State100024720.
- Iron_dependent_repressor type Biomolecule.
- Iron_dependent_repressor type Protein.
- Iron_dependent_repressor type BiologicalObject.
- Iron_dependent_repressor comment "In molecular biology, the iron dependent repressors are a family of bacterial and archaeal transcriptional repressors.At their N-terminus they contain a dtxR-type HTH domain. This is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 65 amino acids present in metalloregulators of the dtxR/mntR family. The domain is named after Corynebacterium diphtheriae dtxR, an iron-specific diphtheria toxin repressor, and Bacillus subtilis mntR, a manganese transport regulator.".
- Iron_dependent_repressor label "Iron dependent repressor".
- Iron_dependent_repressor sameAs m.0h3qkyn.
- Iron_dependent_repressor sameAs Q6072947.
- Iron_dependent_repressor sameAs Q6072947.
- Iron_dependent_repressor sameAs Iron_dependent_repressor.
- Iron_dependent_repressor wasDerivedFrom Iron_dependent_repressor?oldid=591820414.
- Iron_dependent_repressor depiction PDB_1u8r_EBI.jpg.
- Iron_dependent_repressor isPrimaryTopicOf Iron_dependent_repressor.
