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- Iron_response_element abstract "In Molecular biology, the Iron response element or Iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (untranslated regions) of various mRNAs whose products are involved in iron metabolism. For example, the mRNA of ferritin (an iron storage protein) contains one IRE in its 5' UTR. When iron concentration is low, IRPs bind the IRE in the ferritin mRNA and cause reduced translation rates. In contrast, binding to multiple IREs in the 3' UTR of the transferrin receptor (involved in iron acquisition) leads to increased mRNA stability.In high iron conditions in humans, IRP1 binds with an iron-sulphur complex [4Fe-4S] and adopts an aconitase conformation unsuitable for IRE binding. In contrast, IRP2 is degraded in high iron conditions. There is variation in affinity between different IREs and different IRPs. Some IREs can also be affected by alternative gene splicing.The upper helix of the known IREs shows stronger conservation of structure compared to the lower helix. The bases composing the helixes are variable. The mid-stem bulged C is a highly characteristic feature (though this has been seen to be a G in the ferritin IRE for lobster.) The apical loop of the known IREs all consist of either the AGA or AGU triplet. This is pinched by a paired G-C and there is additionally a bulged U, C or A in the upper helix. The crystal structure and NMR data show a bulged U in the lower stem of the ferritin IRE. This is consistent with the predicted secondary structure. IREs in many other mRNAs do not have any support for this bulged U. Consequently two RFAM models have been created for the IRE - one with a bulged U and one without.Genes known to contain IREs include FTH1, FTL, TFRC, ALAS2, Sdhb, ACO2, Hao1, SLC11A2 (encoding DMT1),NDUFS1, SLC40A1 (encoding the ferroportine) CDC42BPA, CDC14A, EPAS1. Many of these genes have clear and direct roles in iron metabolism. Others show a less obvious connection. ACO2 encodes an isomerase catalysing the reversible isomerisation of citrate and iso-citrate. EPAS1 encodes a transcription factor involved in complex oxygen sensing pathways by the induction of oxygen regulated genes under low oxygen conditions. CDC42BPA encodes a kinase with a role in cytoskeletal reorganisation. CDC14A encodes a dual-specificity phosphatase implicated in cell cycle control and also interacts with interphase centrosomes.The IRE is found over a diverse taxonomic range - mainly eukaryotes but not in plants.".
- Iron_response_element thumbnail RF00037.jpg?width=300.
- Iron_response_element wikiPageExternalLink index.html.
- Iron_response_element wikiPageExternalLink RNAMotif?PatID=T0102.
- Iron_response_element wikiPageExternalLink stevens2011a.
- Iron_response_element wikiPageID "11421135".
- Iron_response_element wikiPageRevisionID "592057486".
- Iron_response_element caption "Predicted secondary structure and sequence conservation of IRE".
- Iron_response_element hasPhotoCollection Iron_response_element.
- Iron_response_element id "RF00037".
- Iron_response_element id "RF02253".
- Iron_response_element name "Iron response element - Model I".
- Iron_response_element name "Iron response element - Model II".
- Iron_response_element name "Iron response element".
- Iron_response_element rfam "RF00037".
- Iron_response_element rnaType Cis-regulatory_element.
- Iron_response_element symbol "IRE".
- Iron_response_element taxDomain Eukaryote.
- Iron_response_element subject Category:Cis-regulatory_RNA_elements.
- Iron_response_element type Abstraction100002137.
- Iron_response_element type Cis-regulatoryRNAElements.
- Iron_response_element type Cognition100023271.
- Iron_response_element type Component105868954.
- Iron_response_element type Concept105835747.
- Iron_response_element type Content105809192.
- Iron_response_element type Idea105833840.
- Iron_response_element type Part105867413.
- Iron_response_element type PsychologicalFeature100023100.
- Iron_response_element comment "In Molecular biology, the Iron response element or Iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (untranslated regions) of various mRNAs whose products are involved in iron metabolism. For example, the mRNA of ferritin (an iron storage protein) contains one IRE in its 5' UTR.".
- Iron_response_element label "Iron Response Element".
- Iron_response_element label "Iron response element".
- Iron_response_element sameAs Iron_Response_Element.
- Iron_response_element sameAs Élément_de_réponse_au_fer.
- Iron_response_element sameAs m.02rbyv6.
- Iron_response_element sameAs Q1673083.
- Iron_response_element sameAs Q1673083.
- Iron_response_element sameAs Iron_response_element.
- Iron_response_element wasDerivedFrom Iron_response_element?oldid=592057486.
- Iron_response_element depiction RF00037.jpg.
- Iron_response_element isPrimaryTopicOf Iron_response_element.
