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- Isolated_primary_immunoglobulin_M_deficiency abstract "Isolated primary immunoglobulin M deficiency (or selective IgM immunodeficiency (SIgMD)) is a poorly defined dysgammaglobulinemia characterized by decreased levels of IgM while levels of other immunoglobulins are normal. The immunodeficiency has been associated with some clinical disorders including recurrent infections, atopy, Bloom's syndrome, celiac disease, systemic lupus erythematosus and malignancy, but, surprisingly, SIgMD seems to also occur in asymptomatic individuals. High incidences of recurrent upper respiratory tract infections (77%), asthma (47%) and allergic rhinitis (36%) have also been reported. SIgMD seems to be a particularly rare antibody deficiency with a reported prevalence between 0.03% (general population) and 0.1% (hospitalized patients).The etiology of selective IgM deficiency remains unclear, although various mechanisms have been proposed, such as an increase in regulatory T cell functions, defective T helper cell functions and impaired terminal differentiation of B lymphocytes into IgM-secreting cells among others. It is however puzzling that class switching seems to happen normally (serum levels of other antibodies are normal), while dysfunctioning of IgM synthesis is expected to occur together with abnormalities in other immunoglobulins. Notwithstanding a clear pathogenesis and commonly accepted defenition, a cutoff for SIgMD could be the lower limit of the serum IgM reference range, such as 43 mg/dL in adults or even 20 mg/dL.".
- Isolated_primary_immunoglobulin_M_deficiency emedicineSubject "med".
- Isolated_primary_immunoglobulin_M_deficiency emedicineTopic "3436".
- Isolated_primary_immunoglobulin_M_deficiency icd10 "D80.4".
- Isolated_primary_immunoglobulin_M_deficiency icd9 "279.02".
- Isolated_primary_immunoglobulin_M_deficiency thumbnail IgM_scheme.svg?width=300.
- Isolated_primary_immunoglobulin_M_deficiency wikiPageID "18386524".
- Isolated_primary_immunoglobulin_M_deficiency wikiPageRevisionID "526586210".
- Isolated_primary_immunoglobulin_M_deficiency caption Immunoglobulin_M.
- Isolated_primary_immunoglobulin_M_deficiency emedicinesubj "med".
- Isolated_primary_immunoglobulin_M_deficiency emedicinetopic "3436".
- Isolated_primary_immunoglobulin_M_deficiency hasPhotoCollection Isolated_primary_immunoglobulin_M_deficiency.
- Isolated_primary_immunoglobulin_M_deficiency icd "279.02".
- Isolated_primary_immunoglobulin_M_deficiency icd "D80.4".
- Isolated_primary_immunoglobulin_M_deficiency name "Isolated primary immunoglobulin M deficiency".
- Isolated_primary_immunoglobulin_M_deficiency subject Category:Noninfectious_immunodeficiency-related_cutaneous_conditions.
- Isolated_primary_immunoglobulin_M_deficiency subject Category:Predominantly_antibody_deficiencies.
- Isolated_primary_immunoglobulin_M_deficiency type Abstraction100002137.
- Isolated_primary_immunoglobulin_M_deficiency type Attribute100024264.
- Isolated_primary_immunoglobulin_M_deficiency type Condition113920835.
- Isolated_primary_immunoglobulin_M_deficiency type NoninfectiousImmunodeficiency-relatedCutaneousConditions.
- Isolated_primary_immunoglobulin_M_deficiency type State100024720.
- Isolated_primary_immunoglobulin_M_deficiency type Disease.
- Isolated_primary_immunoglobulin_M_deficiency type AilmentCondition.
- Isolated_primary_immunoglobulin_M_deficiency type Situation.
- Isolated_primary_immunoglobulin_M_deficiency comment "Isolated primary immunoglobulin M deficiency (or selective IgM immunodeficiency (SIgMD)) is a poorly defined dysgammaglobulinemia characterized by decreased levels of IgM while levels of other immunoglobulins are normal. The immunodeficiency has been associated with some clinical disorders including recurrent infections, atopy, Bloom's syndrome, celiac disease, systemic lupus erythematosus and malignancy, but, surprisingly, SIgMD seems to also occur in asymptomatic individuals.".
- Isolated_primary_immunoglobulin_M_deficiency label "Isolated primary immunoglobulin M deficiency".
- Isolated_primary_immunoglobulin_M_deficiency sameAs m.04f3jgr.
- Isolated_primary_immunoglobulin_M_deficiency sameAs Q6085903.
- Isolated_primary_immunoglobulin_M_deficiency sameAs Q6085903.
- Isolated_primary_immunoglobulin_M_deficiency sameAs 606.
- Isolated_primary_immunoglobulin_M_deficiency sameAs Isolated_primary_immunoglobulin_M_deficiency.
- Isolated_primary_immunoglobulin_M_deficiency wasDerivedFrom Isolated_primary_immunoglobulin_M_deficiency?oldid=526586210.
- Isolated_primary_immunoglobulin_M_deficiency depiction IgM_scheme.svg.
- Isolated_primary_immunoglobulin_M_deficiency isPrimaryTopicOf Isolated_primary_immunoglobulin_M_deficiency.
- Isolated_primary_immunoglobulin_M_deficiency name "Isolated primary immunoglobulin M deficiency".
