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- IsomiR abstract "isomiR is a term created by Morin et al. to refer to those sequences that have variations with respect to the reference MiRNA sequence. miRBase is considered to be the gold-standard miRNA database—it stores miRNA sequences detected by thousand of experiments. In this database each miRNA is associated with a miRNA precursor and with one or two mature miRNA (-5p and -3p). In the past it had always been said that the same miRNA precursor generates the same miRNA sequences. However, the advent of deep sequencing has now allowed researchers to detect a huge variability in miRNA biogenesis, meaning that from the same miRNA precursor many different sequences can be generated. There are four main variation types:5' trimming—the 5' dicing site is upstream or downstream from the reference miRNA sequence3' trimming—the 3' dicing site is upstream or downstream from the reference miRNA sequence3' nucleotide addition—nucleotides added to the 3' end of the reference miRNAnucleotide substitution—nucleotides changes from the miRNA precursor. It is thought that may be similar process than post-transcriptional modifications.File:Isomirs.jpg".
- IsomiR thumbnail Isomirs.jpg?width=300.
- IsomiR wikiPageExternalLink seqbuster.
- IsomiR wikiPageExternalLink www.mirbase.org.
- IsomiR wikiPageID "33229822".
- IsomiR wikiPageRevisionID "601367413".
- IsomiR subject Category:Articles_created_via_the_Article_Wizard.
- IsomiR subject Category:MicroRNA.
- IsomiR comment "isomiR is a term created by Morin et al. to refer to those sequences that have variations with respect to the reference MiRNA sequence. miRBase is considered to be the gold-standard miRNA database—it stores miRNA sequences detected by thousand of experiments. In this database each miRNA is associated with a miRNA precursor and with one or two mature miRNA (-5p and -3p). In the past it had always been said that the same miRNA precursor generates the same miRNA sequences.".
- IsomiR label "IsomiR".
- IsomiR sameAs m.0h7plmt.
- IsomiR sameAs Q6086080.
- IsomiR sameAs Q6086080.
- IsomiR wasDerivedFrom IsomiR?oldid=601367413.
- IsomiR depiction Isomirs.jpg.
- IsomiR isPrimaryTopicOf IsomiR.
.%20In%20the%20past%20it%20had%20always%20been%20said%20that%20the%20same%20miRNA%20precursor%20generates%20the%20same%20miRNA%20sequences.%20However%2C%20the%20advent%20of%20deep%20sequencing%20has%20now%20allowed%20researchers%20to%20detect%20a%20huge%20variability%20in%20miRNA%20biogenesis%2C%20meaning%20that%20from%20the%20same%20miRNA%20precursor%20many%20different%20sequences%20can%20be%20generated.%20There%20are%20four%20main%20variation%20types%3A5'%20trimming%E2%80%94the%205'%20dicing%20site%20is%20upstream%20or%20downstream%20from%20the%20reference%20miRNA%20sequence3'%20trimming%E2%80%94the%203'%20dicing%20site%20is%20upstream%20or%20downstream%20from%20the%20reference%20miRNA%20sequence3'%20nucleotide%20addition%E2%80%94nucleotides%20added%20to%20the%203'%20end%20of%20the%20reference%20miRNAnucleotide%20substitution%E2%80%94nucleotides%20changes%20from%20the%20miRNA%20precursor.%20It%20is%20thought%20that%20may%20be%20similar%20process%20than%20post-transcriptional%20modifications.File%3AIsomirs.jpg%22%40en){kind=link}
