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- Ivacaftor abstract "Ivacaftor (trade name Kalydeco, developed as VX-770) is a drug approved for patients with a certain mutation of cystic fibrosis, which accounts for 4–5% cases of cystic fibrosis. Ivacaftor was developed by Vertex Pharmaceuticals in conjunction with the Cystic Fibrosis Foundation. It is one of the most expensive drugs, costing over $300,000 per year, and doctors who developed the drug have criticized Vertex for charging so much. Cystic fibrosis is caused by any one of several defects in a protein, cystic fibrosis transmembrane conductance regulator (CFTR), which regulates fluid flow within cells and affects the components of sweat, digestive fluids, and mucus. The defect, which is caused by the G551D mutation in the individual's DNA, can be in any of several locations along the protein, each of which interferes with a different function of the protein. G551D is a mutation in which the amino acid glycine (G) in position 551 is replaced with aspartic acid (D). G551D is characterized by a dysfunctional CFTR protein on the cell surface. In the case of G551D, the protein is trafficked to the correct area, the epithelial cell surface, but once there the protein cannot transport chloride through the channel. Ivacaftor, a CFTR potentiator, improves the transport of chloride through the ion channel by binding to the channels directly to induce a non-conventional mode of gating which in turn increases the probability that the channel is open.".
- Ivacaftor atcPrefix "R07".
- Ivacaftor atcSuffix "AX02".
- Ivacaftor casNumber "873054-44-5".
- Ivacaftor chEBI "66901".
- Ivacaftor fdaUniiCode "1Y740ILL1Z".
- Ivacaftor iupacName "N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide".
- Ivacaftor pubchem "16220172".
- Ivacaftor thumbnail Ivacaftor.svg?width=300.
- Ivacaftor wikiPageExternalLink VX-770.
- Ivacaftor wikiPageID "30995223".
- Ivacaftor wikiPageRevisionID "600246263".
- Ivacaftor atcPrefix "R07".
- Ivacaftor atcSuffix "AX02".
- Ivacaftor c "24".
- Ivacaftor casNumber "873054".
- Ivacaftor chebi "66901".
- Ivacaftor chemspiderid "17347474".
- Ivacaftor eliminationHalfLife "43200.0".
- Ivacaftor excretion "88".
- Ivacaftor h "28".
- Ivacaftor hasPhotoCollection Ivacaftor.
- Ivacaftor inchi "InChI=1S/C24H28N2O3/c1-2316-11-172012-1926-2215-13-25-18-10-8-7-9-142128/h7-13,27H,1-6H3,".
- Ivacaftor iupacName "N--4-oxo-1,4-dihydroquinoline-3-carboxamide".
- Ivacaftor legalUs "Rx-only".
- Ivacaftor licenceUs "Ivacaftor".
- Ivacaftor metabolism "CYP3A".
- Ivacaftor molecularWeight "392.49".
- Ivacaftor n "2".
- Ivacaftor o "3".
- Ivacaftor pregnancyUs "B".
- Ivacaftor proteinBound "99.0".
- Ivacaftor pubchem "16220172".
- Ivacaftor routesOfAdministration "Oral".
- Ivacaftor smiles "O=C\2c1cN/C=C/2CNc3cccCC".
- Ivacaftor stdinchi "1".
- Ivacaftor stdinchikey "PURKAOJPTOLRMP-UHFFFAOYSA-N".
- Ivacaftor synonyms "VX-770".
- Ivacaftor tradename "Kalydeco".
- Ivacaftor unii "1".
- Ivacaftor verifiedfields "changed".
- Ivacaftor verifiedrevid "477495886".
- Ivacaftor watchedfields "changed".
- Ivacaftor subject Category:Anilides.
- Ivacaftor subject Category:Cystic_fibrosis.
- Ivacaftor subject Category:Phenols.
- Ivacaftor subject Category:Quinolones.
- Ivacaftor type Abstraction100002137.
- Ivacaftor type Chemical114806838.
- Ivacaftor type Compound114818238.
- Ivacaftor type Material114580897.
- Ivacaftor type Matter100020827.
- Ivacaftor type OrganicCompound114727670.
- Ivacaftor type Part113809207.
- Ivacaftor type Phenol114989545.
- Ivacaftor type Phenols.
- Ivacaftor type PhysicalEntity100001930.
- Ivacaftor type Relation100031921.
- Ivacaftor type Substance100019613.
- Ivacaftor type Drug.
- Ivacaftor type FunctionalSubstance.
- Ivacaftor comment "Ivacaftor (trade name Kalydeco, developed as VX-770) is a drug approved for patients with a certain mutation of cystic fibrosis, which accounts for 4–5% cases of cystic fibrosis. Ivacaftor was developed by Vertex Pharmaceuticals in conjunction with the Cystic Fibrosis Foundation. It is one of the most expensive drugs, costing over $300,000 per year, and doctors who developed the drug have criticized Vertex for charging so much.".
- Ivacaftor label "Ivacaftor".
- Ivacaftor label "Ivacaftor".
- Ivacaftor sameAs Ivacaftor.
- Ivacaftor sameAs m.0gg58cr.
- Ivacaftor sameAs Q6095693.
- Ivacaftor sameAs Q6095693.
- Ivacaftor sameAs Ivacaftor.
- Ivacaftor wasDerivedFrom Ivacaftor?oldid=600246263.
- Ivacaftor depiction Ivacaftor.svg.
- Ivacaftor isPrimaryTopicOf Ivacaftor.
