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- JARID2 abstract "Jarid2 (jumonji, AT rich interactive domain 2) is a protein coding gene that functions as a putative transcription factor. Distinguished as a nuclear protein necessary for mouse embryogenesis, Jarid2 is a member of the jumonji family that contains a DNA binding domain known as the AT-rich interaction domain (ARID)[2, 8, 11, 13]. In vitro studies of Jarid2 reveal that ARID along with other functional domains are involved in DNA binding, nuclear localization, transcriptional repression [5], and recruitment of Polycomb-repressive complex 2 (PRC2) [9, 10]. Intracellular mechanisms underlying these interactions remain largely unknown.In search of developmentally important genes, Jarid2 has previously been identified by gene trap technology as an important factor necessary for organ development [2, 3, 5]. During mouse organogenesis, Jarid2 is involved in the formation of the neural tube and development of the liver, spleen, thymus and cardiovascular system [6, 12]. Continuous Jarid2 expression in the tissues of the heart, highlight its presiding role in the development of both the embryonic and the adult heart [2]. Mutant models of Jarid2 embryos show severe heart malformations, ventricular septal defects, noncompaction of the ventricular wall, and dialated atria [4]. Homozygous mutants of Jarid2 are found to die soon after birth [4]. Overexpression of the mouse Jarid2 gene has been reported to repress cardiomyocyte proliferation through it close interaction with retinoblastoma protein (Rb), a master cell cycle regulator [3, 5, 7]. Retinoblastoma-binding protein-2 and the human SMCX protein share regions of homology between mice and humans [1, 14].".
- JARID2 wikiPageID "15215486".
- JARID2 wikiPageRevisionID "606676995".
- JARID2 hasPhotoCollection JARID2.
- JARID2 requireManualInspection "no".
- JARID2 updateCitations "yes".
- JARID2 updatePage "yes".
- JARID2 updateProteinBox "yes".
- JARID2 updateSummary "no".
- JARID2 subject Category:EC_1.14.11.
- JARID2 subject Category:Genes_mutated_in_mice.
- JARID2 subject Category:Human_2OG_oxygenases.
- JARID2 subject Category:Transcription_factors.
- JARID2 comment "Jarid2 (jumonji, AT rich interactive domain 2) is a protein coding gene that functions as a putative transcription factor. Distinguished as a nuclear protein necessary for mouse embryogenesis, Jarid2 is a member of the jumonji family that contains a DNA binding domain known as the AT-rich interaction domain (ARID)[2, 8, 11, 13].".
- JARID2 label "JARID2".
- JARID2 sameAs m.03hm44_.
- JARID2 sameAs Q6107720.
- JARID2 sameAs Q6107720.
- JARID2 wasDerivedFrom JARID2?oldid=606676995.
- JARID2 isPrimaryTopicOf JARID2.