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- KIR3DL1 abstract "Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene.Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte immunoglobulin-like receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.".
- KIR3DL1 entrezgene "3811".
- KIR3DL1 wikiPageID "14754853".
- KIR3DL1 wikiPageRevisionID "599754695".
- KIR3DL1 hasPhotoCollection KIR3DL1.
- KIR3DL1 requireManualInspection "no".
- KIR3DL1 summaryText "Killer cell immunoglobulin-like receptors are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte immunoglobulin-like receptor complex . The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes . The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long or short cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif , while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.".
- KIR3DL1 updateCitations "yes".
- KIR3DL1 updatePage "yes".
- KIR3DL1 updateProteinBox "yes".
- KIR3DL1 updateSummary "no".
- KIR3DL1 subject Category:Clusters_of_differentiation.
- KIR3DL1 subject Category:Immunoglobulin_superfamily.
- KIR3DL1 type Biomolecule.
- KIR3DL1 type Protein.
- KIR3DL1 type BiologicalObject.
- KIR3DL1 comment "Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene.Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte immunoglobulin-like receptor complex (LRC).".
- KIR3DL1 label "KIR3DL1".
- KIR3DL1 sameAs m.03gwrx4.
- KIR3DL1 sameAs Q6331057.
- KIR3DL1 sameAs Q6331057.
- KIR3DL1 sameAs KIR3DL1.
- KIR3DL1 wasDerivedFrom KIR3DL1?oldid=599754695.
- KIR3DL1 isPrimaryTopicOf KIR3DL1.