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- KLKB1 abstract "Plasma kallikrein is a protein that in humans is encoded by the KLKB1 gene.Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.".
- KLKB1 entrezgene "3818".
- KLKB1 wikiPageID "14170070".
- KLKB1 wikiPageRevisionID "606607526".
- KLKB1 hasPhotoCollection KLKB1.
- KLKB1 requireManualInspection "no".
- KLKB1 summaryText "Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.".
- KLKB1 updateCitations "yes".
- KLKB1 updatePage "yes".
- KLKB1 updateProteinBox "yes".
- KLKB1 updateSummary "yes".
- KLKB1 type Biomolecule.
- KLKB1 type Protein.
- KLKB1 type BiologicalObject.
- KLKB1 comment "Plasma kallikrein is a protein that in humans is encoded by the KLKB1 gene.Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond.".
- KLKB1 label "KLKB1".
- KLKB1 sameAs m.03cwqyj.
- KLKB1 sameAs Q6332786.
- KLKB1 sameAs Q6332786.
- KLKB1 sameAs KLKB1.
- KLKB1 wasDerivedFrom KLKB1?oldid=606607526.
- KLKB1 isPrimaryTopicOf KLKB1.