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- Karyopherin_alpha_2 abstract "Importin subunit alpha-2 is a protein that in humans is encoded by the KPNA2 gene.The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import are members of the alpha importin family of karyopherins such as importin subunit alpha-2. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination".
- Karyopherin_alpha_2 entrezgene "3838".
- Karyopherin_alpha_2 wikiPageID "14058681".
- Karyopherin_alpha_2 wikiPageRevisionID "591984062".
- Karyopherin_alpha_2 hasPhotoCollection Karyopherin_alpha_2.
- Karyopherin_alpha_2 requireManualInspection "no".
- Karyopherin_alpha_2 updateCitations "yes".
- Karyopherin_alpha_2 updatePage "yes".
- Karyopherin_alpha_2 updateProteinBox "yes".
- Karyopherin_alpha_2 updateSummary "yes".
- Karyopherin_alpha_2 type Biomolecule.
- Karyopherin_alpha_2 type Protein.
- Karyopherin_alpha_2 type BiologicalObject.
- Karyopherin_alpha_2 comment "Importin subunit alpha-2 is a protein that in humans is encoded by the KPNA2 gene.The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex.".
- Karyopherin_alpha_2 label "Karyopherin alpha 2".
- Karyopherin_alpha_2 sameAs m.03cs9rm.
- Karyopherin_alpha_2 sameAs Q6373874.
- Karyopherin_alpha_2 sameAs Q6373874.
- Karyopherin_alpha_2 wasDerivedFrom Karyopherin_alpha_2?oldid=591984062.
- Karyopherin_alpha_2 isPrimaryTopicOf Karyopherin_alpha_2.