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- Knockout_rat abstract "A knockout rat is a genetically engineered rat with a single gene turned off through a targeted mutation (gene trapping) used for academic and pharmaceutical research. Knockout rats can mimic human diseases and are important tools for studying gene function (functional genomics) and for drug discovery and development. The production of knockout rats was not economically or technically feasible until 2008.Technology developed through funding from the National Institutes of Health (NIH) and work accomplished by the members of the Knock Out Rat Consortium (KORC) led to cost-effective methods to create knockout rats. The importance of developing the rat as a more versatile tool for human health research is evidenced by the $120 million investment made by the NIH via the Rat Genome Sequencing Project Consortium, resulting in the draft sequence of the Brown Norway laboratory rat (Rattus norvegicus). Additional developments with zinc finger nuclease technology in 2009 led to the first knockout rat with targeted, germline-transmitted mutations. Knockout rat disease models for Parkinson's, Alzheimer's, hypertension, and diabetes using zinc-finger nuclease technology are being commercialized by SAGE Labs.".
- Knockout_rat thumbnail Knockout_rat.jpg?width=300.
- Knockout_rat wikiPageExternalLink piggyBac.
- Knockout_rat wikiPageExternalLink 11511308.
- Knockout_rat wikiPageExternalLink www.knockoutrat.org.
- Knockout_rat wikiPageExternalLink www.nih.gov.
- Knockout_rat wikiPageExternalLink rat.
- Knockout_rat wikiPageExternalLink www.sageresearchmodels.com.
- Knockout_rat wikiPageExternalLink www.transposagenbio.com.
- Knockout_rat wikiPageID "18771661".
- Knockout_rat wikiPageRevisionID "574588044".
- Knockout_rat hasPhotoCollection Knockout_rat.
- Knockout_rat subject Category:Animal_testing.
- Knockout_rat subject Category:Genetically_modified_organisms.
- Knockout_rat subject Category:Rats.
- Knockout_rat type GeneticallyModifiedOrganisms.
- Knockout_rat type LivingThing100004258.
- Knockout_rat type Object100002684.
- Knockout_rat type Organism100004475.
- Knockout_rat type PhysicalEntity100001930.
- Knockout_rat type Whole100003553.
- Knockout_rat comment "A knockout rat is a genetically engineered rat with a single gene turned off through a targeted mutation (gene trapping) used for academic and pharmaceutical research. Knockout rats can mimic human diseases and are important tools for studying gene function (functional genomics) and for drug discovery and development.".
- Knockout_rat label "Knockout rat".
- Knockout_rat sameAs m.04gs4mx.
- Knockout_rat sameAs Q6422932.
- Knockout_rat sameAs Q6422932.
- Knockout_rat sameAs Knockout_rat.
- Knockout_rat wasDerivedFrom Knockout_rat?oldid=574588044.
- Knockout_rat depiction Knockout_rat.jpg.
- Knockout_rat isPrimaryTopicOf Knockout_rat.
