Matches in DBpedia 2014 for { <http://dbpedia.org/resource/LATS1> ?p ?o. }
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- LATS1 abstract "Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.It has been associated with the Hippo signaling pathway.The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.".
- LATS1 entrezgene "9113".
- LATS1 wikiPageID "14798200".
- LATS1 wikiPageRevisionID "592158213".
- LATS1 hasPhotoCollection LATS1.
- LATS1 requireManualInspection "no".
- LATS1 summaryText "The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.".
- LATS1 updateCitations "yes".
- LATS1 updatePage "yes".
- LATS1 updateProteinBox "yes".
- LATS1 updateSummary "yes".
- LATS1 type Biomolecule.
- LATS1 type Protein.
- LATS1 type BiologicalObject.
- LATS1 comment "Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.It has been associated with the Hippo signaling pathway.The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase.".
- LATS1 label "LATS1".
- LATS1 sameAs m.03gyb7d.
- LATS1 sameAs Q6457139.
- LATS1 sameAs Q6457139.
- LATS1 wasDerivedFrom LATS1?oldid=592158213.
- LATS1 isPrimaryTopicOf LATS1.