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- LIMK2 abstract "LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.".
- LIMK2 entrezgene "3985".
- LIMK2 wikiPageExternalLink report.cgi?report=orth_overview&gene_id=3985.
- LIMK2 wikiPageExternalLink index.shtml.
- LIMK2 wikiPageID "14764581".
- LIMK2 wikiPageRevisionID "592193410".
- LIMK2 hasPhotoCollection LIMK2.
- LIMK2 requireManualInspection "no".
- LIMK2 summaryText "There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.".
- LIMK2 updateCitations "yes".
- LIMK2 updatePage "yes".
- LIMK2 updateProteinBox "yes".
- LIMK2 updateSummary "yes".
- LIMK2 type Biomolecule.
- LIMK2 type Protein.
- LIMK2 type BiologicalObject.
- LIMK2 comment "LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions.".
- LIMK2 label "LIMK2".
- LIMK2 sameAs m.03gx6xl.
- LIMK2 sameAs Q6458715.
- LIMK2 sameAs Q6458715.
- LIMK2 wasDerivedFrom LIMK2?oldid=592193410.
- LIMK2 isPrimaryTopicOf LIMK2.