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- LSm abstract "In biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism. LSm is a contraction of 'like Sm', because the first identified members of the LSm protein family were the Sm proteins. LSm proteins are defined by a characteristic three-dimensional structure and their assembly into rings of six or seven individual LSm protein molecules.The Sm proteins were first discovered as antigens targeted by so-called Anti-Sm antibodies in a patient with a form of Systemic lupus erythematosus (SLE), a debilitating autoimmune disease. They were named Sm proteins in honor of Stephanie Smith, a patient who suffered from SLE. Other proteins with very similar structures were subsequently discovered and named LSm proteins. New members of the LSm protein family continue to be identified and reported.Proteins with similar structures are grouped into a hierarchy of protein families, superfamilies, and folds. The LSm protein structure is an example of a small beta sheet folded into a short barrel. Individual LSm proteins assemble into a six or seven member doughnut ring (more properly termed a torus), which usually binds to a small RNA molecule to form a ribonucleoprotein complex. The LSm torus assists the RNA molecule to assume and maintain its proper three-dimensional structure. Depending on which LSm proteins and RNA molecule are involved, this ribonucleoprotein complex facilitates a wide variety of RNA processing including degradation, editing, splicing, and regulation.Alternate terms for LSm family are LSm fold and Sm-like fold, and alternate capitalization styles such as lsm, LSM, and Lsm are common and equally acceptable.".
- LSm symbol "LSM".
- LSm thumbnail LSm_1I5L_1.JPG?width=300.
- LSm wikiPageExternalLink family?entry=PF01423.
- LSm wikiPageID "8874156".
- LSm wikiPageRevisionID "596572651".
- LSm caption "crystal structure of the sm-related protein of p. abyssi the biological unit is a heptamer".
- LSm hasPhotoCollection LSm.
- LSm interpro "IPR001163".
- LSm name "LSM domain".
- LSm pfam "PF01423".
- LSm scop "1".
- LSm symbol "LSM".
- LSm subject Category:Proteins.
- LSm subject Category:Spliceosome.
- LSm type Abstraction100002137.
- LSm type Chemical114806838.
- LSm type Compound114818238.
- LSm type Macromolecule114944888.
- LSm type Material114580897.
- LSm type Matter100020827.
- LSm type Molecule114682133.
- LSm type OrganicCompound114727670.
- LSm type Part113809207.
- LSm type PhysicalEntity100001930.
- LSm type Protein114728724.
- LSm type Proteins.
- LSm type Relation100031921.
- LSm type Substance100019613.
- LSm type Thing100002452.
- LSm type Unit109465459.
- LSm type Biomolecule.
- LSm type Protein.
- LSm type BiologicalObject.
- LSm comment "In biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism. LSm is a contraction of 'like Sm', because the first identified members of the LSm protein family were the Sm proteins.".
- LSm label "LSm".
- LSm label "Protéines LSm".
- LSm sameAs Protéines_LSm.
- LSm sameAs m.027mwdb.
- LSm sameAs Q3408235.
- LSm sameAs Q3408235.
- LSm sameAs LSm.
- LSm wasDerivedFrom LSm?oldid=596572651.
- LSm depiction LSm_1I5L_1.JPG.
- LSm isPrimaryTopicOf LSm.
