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- Laser_Ablation_Electrospray_Ionization abstract "Laser Ablation Electrospray Ionization (LAESI) is an ambient ionization method for mass spectrometry that combines laser ablation from a mid-infrared (mid-IR) laser with a secondary electrospray ionization (ESI) process. The mid-IR laser is used to generate gas phase particles which are then ionized through interactions with charged droplets from the ESI source. LAESI was developed by Professor Akos Vertes and Dr. Peter Nemes in 2007 and is now marketed commercially by Protea Biosciences, Inc. LAESI is a novel ionization source for mass spectrometry (MS) that has been used to perform MS imaging of plants, tissues, cell pellets, and even single cells. In addition, LAESI has been used to analyze historic documents and untreated biofluids such as urine and blood. The technique of LAESI is performed at atmospheric pressure and therefore overcomes many of the obstacles of traditional MS techniques, including extensive and invasive sample preparation steps and the use of high vacuum. LAESI can be used to perform MS analysis of many different classes of compounds ranging from small molecules, such as pharmaceuticals, saccharides, lipids, and metabolites to larger biomolecules like peptides and proteins. LAESI has also been shown to have a quantitative dynamic range of 4 decades and a limit of detection (LOD) of 8 fmol with verapamil, a small pharmaceutical molecule. The technique has a lateral resolution of <200 μm for imaging applications and has been used for 3D imaging of plant tissues. Additionally, in cell-by-cell LAESI imaging experiments single cells can be used as the pixels of the molecular image. This LAESI application uses etched optical fibers to produce laser spot sizes of <50 µm to deliver the laser energy and has also been utilized in single cell analysis experiments.".
- Laser_Ablation_Electrospray_Ionization thumbnail LAESI_OverviewGif.gif?width=300.
- Laser_Ablation_Electrospray_Ionization wikiPageExternalLink ~vertes.
- Laser_Ablation_Electrospray_Ionization wikiPageExternalLink laesi.
- Laser_Ablation_Electrospray_Ionization wikiPageID "30972650".
- Laser_Ablation_Electrospray_Ionization wikiPageRevisionID "533164218".
- Laser_Ablation_Electrospray_Ionization hasPhotoCollection Laser_Ablation_Electrospray_Ionization.
- Laser_Ablation_Electrospray_Ionization subject Category:Ion_source.
- Laser_Ablation_Electrospray_Ionization subject Category:Mass_spectrometry.
- Laser_Ablation_Electrospray_Ionization comment "Laser Ablation Electrospray Ionization (LAESI) is an ambient ionization method for mass spectrometry that combines laser ablation from a mid-infrared (mid-IR) laser with a secondary electrospray ionization (ESI) process. The mid-IR laser is used to generate gas phase particles which are then ionized through interactions with charged droplets from the ESI source. LAESI was developed by Professor Akos Vertes and Dr. Peter Nemes in 2007 and is now marketed commercially by Protea Biosciences, Inc.".
- Laser_Ablation_Electrospray_Ionization label "Laser Ablation Electrospray Ionization".
- Laser_Ablation_Electrospray_Ionization sameAs m.011c82xv.
- Laser_Ablation_Electrospray_Ionization sameAs Q6492974.
- Laser_Ablation_Electrospray_Ionization sameAs Q6492974.
- Laser_Ablation_Electrospray_Ionization wasDerivedFrom Laser_Ablation_Electrospray_Ionization?oldid=533164218.
- Laser_Ablation_Electrospray_Ionization depiction LAESI_OverviewGif.gif.
- Laser_Ablation_Electrospray_Ionization isPrimaryTopicOf Laser_Ablation_Electrospray_Ionization.
