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- Levorphanol abstract "Levorphanol (Levo-Dromoran) is an opioid medication used to treat moderate to severe pain. It is the levorotatory stereoisomer of the synthetic morphinan (Dromoran) and a pure opioid agonist, first described in Germany in 1948 as an orally active morphine-like analgesic. Morphinan is the parent drug and prototype of a large series of opioid and/or NMDA antagonists and opioid agonists used in medicine including nalbuphine, butorphanol, dextromethorphan (which is not an opioid agonist), and others.Levorphanol labeled with tritium was used in the research which led to the discovery of opioid receptors in the human nervous system, including the first study published in 1971.Levorphanol has the same properties as morphine with respect to the potential for habituation, tolerance, physical dependence and withdrawal syndrome. It is 4 to 8 times as potent as morphine and has a longer half-life. Approximately 30 mg of oral morphine is roughly equianalgesic to 4 mg of oral levorphanol. The levo isomer is the source of the narcotic properties of the racemic drug Dromoran, but the dextro isomers are also useful in medicine: in addition to acting on sigma receptors, the O-methyl derivative of its dextrorotary isomer, dextromethorphan, is a common NMDA receptor antagonist and pro-drug to dextrorphan. Oral doses of levorphanol come in 2 mg and 4 mg strengths or subcutaneous injection every 6 to 8 hours.Levorphanol has affinity to μ, κ, and δ opioid receptors, but lacks complete cross-tolerance with morphine. The duration of action is generally long compared to other comparable analgesics, and varies from 4 hours to as much as 15 hours. For this reason levorphanol is useful in palliation of chronic pain and similar conditions. Levorphanol has an oral to parenteral effectiveness ratio of 2:1, one of the most favourable of the strong narcotics. Its NMDA actions, similar to those of the phenylheptylamine open-chain narcotics such as methadone or the phenylpiperidine ketobemidone, make levorphanol useful for types of pain that other analgesics may not be as effective against; levorphanol's sigma receptor, SNRI properties make it even more useful particularly for neuropathic pain.".
- Levorphanol atcPrefix "None".
- Levorphanol bioavailability "100.0".
- Levorphanol bioavailability "70.0".
- Levorphanol casNumber "77-07-6".
- Levorphanol drugbank "DB00854".
- Levorphanol fdaUniiCode "27618J1N2X".
- Levorphanol iupacName "17-methylmorphinan-3-ol".
- Levorphanol pubchem "5359272".
- Levorphanol thumbnail Levorphanol2DACS.svg?width=300.
- Levorphanol wikiPageID "4884363".
- Levorphanol wikiPageRevisionID "606465196".
- Levorphanol atcPrefix "None".
- Levorphanol bioavailability "70".
- Levorphanol c "17".
- Levorphanol casNumber "77".
- Levorphanol chembl "592".
- Levorphanol chemspiderid "16736212".
- Levorphanol dependencyLiability "High".
- Levorphanol drugName "Levorphanol".
- Levorphanol drugbank "DB00854".
- Levorphanol eliminationHalfLife "-57600.0".
- Levorphanol h "23".
- Levorphanol hasPhotoCollection Levorphanol.
- Levorphanol image "Levorphanol3DanJ.gif".
- Levorphanol inchi "1".
- Levorphanol inchikey "JAQUASYNZVUNQP-USXIJHARBM".
- Levorphanol iupacName "17".
- Levorphanol kegg "D08123".
- Levorphanol legalAu "S8".
- Levorphanol legalCa "Schedule I".
- Levorphanol legalStatus "Class A".
- Levorphanol legalUs "Schedule II".
- Levorphanol medlineplus "a682020".
- Levorphanol metabolism Liver.
- Levorphanol molecularWeight "257.371".
- Levorphanol n "1".
- Levorphanol o "1".
- Levorphanol pregnancyUs "C".
- Levorphanol proteinBound "40.0".
- Levorphanol pubchem "5359272".
- Levorphanol routesOfAdministration "oral, intravenous, subcutaneous, intramuscular".
- Levorphanol smiles "CN1CC[C@]23CCCC[C@H]2[C@H]1CC4=C3C=CC=C4".
- Levorphanol stdinchi "1".
- Levorphanol stdinchikey "JAQUASYNZVUNQP-USXIJHARSA-N".
- Levorphanol tradename "Levo-dromoran".
- Levorphanol unii "27618".
- Levorphanol verifiedfields "changed".
- Levorphanol verifiedrevid "458437606".
- Levorphanol watchedfields "changed".
- Levorphanol width "200".
- Levorphanol width "300".
- Levorphanol subject Category:Enantiopure_drugs.
- Levorphanol subject Category:Euphoriants.
- Levorphanol subject Category:German_inventions.
- Levorphanol subject Category:Morphinans.
- Levorphanol subject Category:Mu-opioid_agonists.
- Levorphanol subject Category:Phenols.
- Levorphanol subject Category:Synthetic_opioids.
- Levorphanol type Ability105616246.
- Levorphanol type Abstraction100002137.
- Levorphanol type Chemical114806838.
- Levorphanol type Cognition100023271.
- Levorphanol type Compound114818238.
- Levorphanol type Creativity105624700.
- Levorphanol type GermanInventions.
- Levorphanol type Invention105633385.
- Levorphanol type Material114580897.
- Levorphanol type Matter100020827.
- Levorphanol type OrganicCompound114727670.
- Levorphanol type Part113809207.
- Levorphanol type Phenol114989545.
- Levorphanol type Phenols.
- Levorphanol type PhysicalEntity100001930.
- Levorphanol type PsychologicalFeature100023100.
- Levorphanol type Relation100031921.
- Levorphanol type Substance100019613.
- Levorphanol type Drug.
- Levorphanol type DrugProduct.
- Levorphanol type FunctionalSubstance.
- Levorphanol comment "Levorphanol (Levo-Dromoran) is an opioid medication used to treat moderate to severe pain. It is the levorotatory stereoisomer of the synthetic morphinan (Dromoran) and a pure opioid agonist, first described in Germany in 1948 as an orally active morphine-like analgesic.".
- Levorphanol label "Levorfanol".
- Levorphanol label "Levorphanol".
- Levorphanol label "Leworfanol".
- Levorphanol label "Леворфанол".
- Levorphanol sameAs Levorfanol.
- Levorphanol sameAs Antalgin.
- Levorphanol sameAs Leworfanol.
- Levorphanol sameAs m.0cshrt.
- Levorphanol sameAs Q2579108.
- Levorphanol sameAs Q2579108.
- Levorphanol sameAs levorphanol.
- Levorphanol sameAs DB00854.
- Levorphanol sameAs Levorphanol.
- Levorphanol wasDerivedFrom Levorphanol?oldid=606465196.
- Levorphanol depiction Levorphanol2DACS.svg.
- Levorphanol isPrimaryTopicOf Levorphanol.
- Levorphanol name "Levorphanol".