Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Linopirdine> ?p ?o. }
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- Linopirdine abstract "Linopirdine is a putative cognition-enhancing drug with a novel mechanism of action. Linopirdine blocks the KCNQ2\3 heteromer M current with an IC50 of 2.4nM disinhibiting acetylcholine release, and increasing hippocampal CA3-schaffer collateral mediated glutamate release onto CA1 pyramidal neurons. In a murine model linopirdine is able to nearly completely reverse the senescence-related decline in cortical c-FOS, an effect which is blocked by atropine and MK-801, suggesting Linopirdine can compensate for the age related decline in acetylcholine release. Linopirdine also blocks homomeric KCNQ1 and KCNQ4 voltage gated potassium channels which contribute to vascular tone with substantially less selectivity than KCNQ2/3.".
- Linopirdine atcPrefix "N06".
- Linopirdine atcSuffix "BX09".
- Linopirdine casNumber "105431-72-9".
- Linopirdine fdaUniiCode "I5TB3NZ94T".
- Linopirdine iupacName "1-phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one".
- Linopirdine pubchem "3932".
- Linopirdine thumbnail Linopirdine.png?width=300.
- Linopirdine wikiPageID "12498930".
- Linopirdine wikiPageRevisionID "577976203".
- Linopirdine atcPrefix "N06".
- Linopirdine atcSuffix "BX09".
- Linopirdine c "26".
- Linopirdine casNumber "105431".
- Linopirdine chembl "319111".
- Linopirdine chemspiderid "3795".
- Linopirdine h "21".
- Linopirdine hasPhotoCollection Linopirdine.
- Linopirdine inchi "1".
- Linopirdine inchikey "YEJCDKJIEMIWRQ-UHFFFAOYAH".
- Linopirdine iupacName "1".
- Linopirdine iupharLigand "2599".
- Linopirdine kegg "D04741".
- Linopirdine molecularWeight "391.465".
- Linopirdine n "3".
- Linopirdine o "1".
- Linopirdine pubchem "3932".
- Linopirdine smiles "O=C2Nc5ccccc5".
- Linopirdine stdinchi "1".
- Linopirdine stdinchikey "YEJCDKJIEMIWRQ-UHFFFAOYSA-N".
- Linopirdine unii "I5TB3NZ94T".
- Linopirdine verifiedfields "changed".
- Linopirdine verifiedrevid "462091934".
- Linopirdine subject Category:Indolines.
- Linopirdine subject Category:Lactams.
- Linopirdine subject Category:Nootropics.
- Linopirdine subject Category:Potassium_channel_blockers.
- Linopirdine subject Category:Pyridines.
- Linopirdine type Athlete109820263.
- Linopirdine type Blocker109860248.
- Linopirdine type CausalAgent100007347.
- Linopirdine type Contestant109613191.
- Linopirdine type FootballPlayer110101634.
- Linopirdine type LivingThing100004258.
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- Linopirdine type Person100007846.
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- Linopirdine type PotassiumChannelBlockers.
- Linopirdine type Whole100003553.
- Linopirdine type YagoLegalActor.
- Linopirdine type YagoLegalActorGeo.
- Linopirdine type Drug.
- Linopirdine type DrugProduct.
- Linopirdine type FunctionalSubstance.
- Linopirdine comment "Linopirdine is a putative cognition-enhancing drug with a novel mechanism of action. Linopirdine blocks the KCNQ2\3 heteromer M current with an IC50 of 2.4nM disinhibiting acetylcholine release, and increasing hippocampal CA3-schaffer collateral mediated glutamate release onto CA1 pyramidal neurons.".
- Linopirdine label "Linopirdine".
- Linopirdine sameAs m.02w93kk.
- Linopirdine sameAs Q6554730.
- Linopirdine sameAs Q6554730.
- Linopirdine sameAs Linopirdine.
- Linopirdine wasDerivedFrom Linopirdine?oldid=577976203.
- Linopirdine depiction Linopirdine.png.
- Linopirdine isPrimaryTopicOf Linopirdine.
