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- Locked_nucleic_acid abstract "A locked nucleic acid (LNA), often referred to as inaccessible RNA, is a modified RNA nucleotide. The ribose moiety of an LNA nucleotide is modified with an extra bridge connecting the 2' oxygen and 4' carbon. The bridge "locks" the ribose in the 3'-endo (North) conformation, which is often found in the A-form duplexes. LNA nucleotides can be mixed with DNA or RNA residues in the oligonucleotide whenever desired. Such oligomers are synthesized chemically and are commercially available. The locked ribose conformation enhances base stacking and backbone pre-organization. This significantly increases the hybridization properties (melting temperature) of oligonucleotides.LNA was independently synthesized by the group of Jesper Wengel in 1998, soon after the first synthesis by the group of Takeshi Imanishi in 1997. The exclusive rights to the LNA technology were secured in 1997 by Exiqon A/S, a Danish biotech company.LNA nucleotides are used to increase the sensitivity and specificity of expression in DNA microarrays, FISH probes, quantitative PCR probes and other molecular biology techniques based on oligonucleotides. For the in situ detection of miRNA the use of LNA is currently (2005) the only efficient method. A triplet of LNA nucleotides surrounding a single-base mismatch site maximizes LNA probe specificity unless the probe contains the guanine base of G-T mismatch.Using LNA based oligonucleotides therapeutically is an emerging field in biotechnology. The Danish pharmaceutical company Santaris Pharma a/s owns the sole rights to therapeutic uses of LNA technology, and is now developing a new, LNA based, hepatitis C drug called miravirsen, targeting miR-122, which is in Phase II clinical testing as of late 2010.An LNA-specific molecular dynamics (MD) force field has been created which is able to accurately model LNA MD.".
- Locked_nucleic_acid thumbnail LNASchem.svg?width=300.
- Locked_nucleic_acid wikiPageExternalLink biophysics.idtdna.com.
- Locked_nucleic_acid wikiPageExternalLink S0167779902000380.
- Locked_nucleic_acid wikiPageExternalLink nl048246f.html.
- Locked_nucleic_acid wikiPageExternalLink Bridged-nucleic-Acids-%28BNA%29-BNA3.aspx.
- Locked_nucleic_acid wikiPageExternalLink oligo-tools.
- Locked_nucleic_acid wikiPageExternalLink index.php?pid=80.
- Locked_nucleic_acid wikiPageID "508492".
- Locked_nucleic_acid wikiPageRevisionID "597076108".
- Locked_nucleic_acid hasPhotoCollection Locked_nucleic_acid.
- Locked_nucleic_acid subject Category:Nucleic_acids.
- Locked_nucleic_acid type Abstraction100002137.
- Locked_nucleic_acid type Chemical114806838.
- Locked_nucleic_acid type Compound114818238.
- Locked_nucleic_acid type Macromolecule114944888.
- Locked_nucleic_acid type Material114580897.
- Locked_nucleic_acid type Matter100020827.
- Locked_nucleic_acid type Molecule114682133.
- Locked_nucleic_acid type NucleicAcid114964129.
- Locked_nucleic_acid type NucleicAcids.
- Locked_nucleic_acid type OrganicCompound114727670.
- Locked_nucleic_acid type Part113809207.
- Locked_nucleic_acid type PhysicalEntity100001930.
- Locked_nucleic_acid type Relation100031921.
- Locked_nucleic_acid type Substance100019613.
- Locked_nucleic_acid type Thing100002452.
- Locked_nucleic_acid type Unit109465459.
- Locked_nucleic_acid comment "A locked nucleic acid (LNA), often referred to as inaccessible RNA, is a modified RNA nucleotide. The ribose moiety of an LNA nucleotide is modified with an extra bridge connecting the 2' oxygen and 4' carbon. The bridge "locks" the ribose in the 3'-endo (North) conformation, which is often found in the A-form duplexes. LNA nucleotides can be mixed with DNA or RNA residues in the oligonucleotide whenever desired. Such oligomers are synthesized chemically and are commercially available.".
- Locked_nucleic_acid label "Acide nucléique bloqué".
- Locked_nucleic_acid label "LNA (Nukleinsäure)".
- Locked_nucleic_acid label "Locked nucleic acid".
- Locked_nucleic_acid label "Ácido nucleico bloqueado".
- Locked_nucleic_acid label "鎖核酸".
- Locked_nucleic_acid sameAs LNA_(Nukleinsäure).
- Locked_nucleic_acid sameAs Ácido_nucleico_bloqueado.
- Locked_nucleic_acid sameAs Acide_nucléique_bloqué.
- Locked_nucleic_acid sameAs m.02jsmd.
- Locked_nucleic_acid sameAs Q418639.
- Locked_nucleic_acid sameAs Q418639.
- Locked_nucleic_acid sameAs Locked_nucleic_acid.
- Locked_nucleic_acid wasDerivedFrom Locked_nucleic_acid?oldid=597076108.
- Locked_nucleic_acid depiction LNASchem.svg.
- Locked_nucleic_acid isPrimaryTopicOf Locked_nucleic_acid.
