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- Locus_control_region abstract "Locus control regions (LCR) are defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. The concept derives from the idea that developmental and cell lineage-specific regulation of gene expression relies not only on gene-proximal elements such as promoters, enhancers, and silencers, but also on long-range interactions of various cis-regulatory elements and dynamic chromatin alterations.The LCR was identified over 20 years ago. In transgenic mouse studies it was determined that the LCR was required for normal regulation of beta-globin gene expression. Several models exist for how the LCR exerts its effects on transcription from a distance.Looping model LCR section of the DNA loops around to different extent over the desired gene of expression, so that the binding site of the transcriptional machinery (proteins) is in physical close proximity to bridge and affect the transcription of that specific gene.↑ ↑".
- Locus_control_region wikiPageID "6043341".
- Locus_control_region wikiPageRevisionID "592307939".
- Locus_control_region hasPhotoCollection Locus_control_region.
- Locus_control_region subject Category:Epigenetics.
- Locus_control_region comment "Locus control regions (LCR) are defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites.".
- Locus_control_region label "Locus control region".
- Locus_control_region label "Région de contrôle du locus".
- Locus_control_region label "基因座控制区".
- Locus_control_region sameAs Région_de_contrôle_du_locus.
- Locus_control_region sameAs m.0fm4sl.
- Locus_control_region sameAs Q3455568.
- Locus_control_region sameAs Q3455568.
- Locus_control_region wasDerivedFrom Locus_control_region?oldid=592307939.
- Locus_control_region isPrimaryTopicOf Locus_control_region.