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- Losmapimod abstract "Losmapimod (GW856553X) is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.p38 mitogen-activated protein kinases are mediators of inflammation. A Phase II human clinical trial for the treatment of COPD (chronic obstructive pulmonary disease) is underway. Inhibiting these enzymes has been shown to produce antidepressant and antipsychotic effects in animal studies, with the mechanism thought to involve increased neurogenesis probably related to BDNF release. Losmapimod has completed Phase II human clinical trials for the treatment of depression although its safety and efficacy have yet to be proven in further trials.Losmapimod is also being studied for cardiovascular disease. A Phase II trial to study its effects in myocardial infarction (heart attack) is ongoing.".
- Losmapimod casNumber "585543-15-3".
- Losmapimod fdaUniiCode "F2DQF16BXE".
- Losmapimod iupacName "6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide".
- Losmapimod pubchem "11552706".
- Losmapimod thumbnail Losmapimod.svg?width=300.
- Losmapimod wikiPageID "24932026".
- Losmapimod wikiPageRevisionID "574715147".
- Losmapimod c "22".
- Losmapimod casNumber "585543".
- Losmapimod chembl "1088752".
- Losmapimod f "1".
- Losmapimod h "26".
- Losmapimod hasPhotoCollection Losmapimod.
- Losmapimod iupacName "6".
- Losmapimod kegg "D09639".
- Losmapimod legalStatus "investigational new drug".
- Losmapimod molecularWeight "383.458".
- Losmapimod n "3".
- Losmapimod o "2".
- Losmapimod pubchem "11552706".
- Losmapimod smiles "C3CC3NCccc1-cncc2CNCCC".
- Losmapimod unii "F2DQF16BXE".
- Losmapimod verifiedfields "changed".
- Losmapimod verifiedrevid "444926440".
- Losmapimod watchedfields "changed".
- Losmapimod subject Category:Protein_kinase_inhibitors.
- Losmapimod type Inhibitor114724436.
- Losmapimod type Matter100020827.
- Losmapimod type PhysicalEntity100001930.
- Losmapimod type ProteinKinaseInhibitors.
- Losmapimod type Substance100020090.
- Losmapimod type Drug.
- Losmapimod type DrugProduct.
- Losmapimod type FunctionalSubstance.
- Losmapimod comment "Losmapimod (GW856553X) is a drug developed by GlaxoSmithKline which acts as a selective inhibitor of the enzyme family known as p38 mitogen-activated protein kinases.p38 mitogen-activated protein kinases are mediators of inflammation. A Phase II human clinical trial for the treatment of COPD (chronic obstructive pulmonary disease) is underway.".
- Losmapimod label "Losmapimod".
- Losmapimod sameAs m.09ggpbg.
- Losmapimod sameAs Q6683687.
- Losmapimod sameAs Q6683687.
- Losmapimod sameAs Losmapimod.
- Losmapimod wasDerivedFrom Losmapimod?oldid=574715147.
- Losmapimod depiction Losmapimod.svg.
- Losmapimod isPrimaryTopicOf Losmapimod.
