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- MACPF abstract "The MACPF protein superfamily is named after a domain that is common to the Membrane Attack Complex proteins (MAC) of complement (C6, C7, C8α, C8β and C9) and perforin (PF). Many members of this protein family are important eukaryote pore forming toxins.The archetypal members of the family are complement C9 and perforin, both of which function in human immunity. C9 functions by punching holes in the membrane of pathogenic Gram-negative bacteria. Perforin is released by cytotoxic T cells and lyses virally infected and transformed cells. In addition perforin permits delivery of cytotoxic proteases called granzymes that cause cell death. Deficiency of either protein can result in human disease. Structural studies reveal that MACPF domains are related to cholesterol dependent cytolysins (CDCs), a family of pore forming toxins previously thought to only exist in bacteria.".
- MACPF symbol "MACPF".
- MACPF thumbnail Paintingmacpf.jpg?width=300.
- MACPF wikiPageExternalLink whisstock.
- MACPF wikiPageExternalLink do_annotation.pl?ACC=SM00457.
- MACPF wikiPageExternalLink facultyStaffDetails.asp?SID=39.
- MACPF wikiPageExternalLink DiseaseInformation.asp.
- MACPF wikiPageExternalLink www.histio.org.
- MACPF wikiPageExternalLink home.
- MACPF wikiPageExternalLink bird.html.
- MACPF wikiPageExternalLink default.php?doc_id=36&title=Cancer+Cell+Death.
- MACPF wikiPageExternalLink explore.do?structureId=1ERG.
- MACPF wikiPageExternalLink explore.do?structureId=1PFO.
- MACPF wikiPageExternalLink explore.do?structureId=2QOS.
- MACPF wikiPageExternalLink explore.do?structureId=2QP2.
- MACPF wikiPageExternalLink getacc?PF01823.
- MACPF wikiPageID "12936761".
- MACPF wikiPageRevisionID "554167489".
- MACPF hasPhotoCollection MACPF.
- MACPF interpro "IPR001862".
- MACPF name "MAC/Perforin domain".
- MACPF pfam "PF01823".
- MACPF prosite "PDOC00251".
- MACPF smart "MACPF".
- MACPF symbol "MACPF".
- MACPF tcdb "1".
- MACPF subject Category:Membrane_proteins.
- MACPF subject Category:Protein_domains.
- MACPF subject Category:Protein_families.
- MACPF type Abstraction100002137.
- MACPF type Attribute100024264.
- MACPF type Chemical114806838.
- MACPF type Compound114818238.
- MACPF type Environment113934596.
- MACPF type Macromolecule114944888.
- MACPF type Material114580897.
- MACPF type Matter100020827.
- MACPF type MembraneProteins.
- MACPF type Molecule114682133.
- MACPF type OrganicCompound114727670.
- MACPF type Part113809207.
- MACPF type PhysicalEntity100001930.
- MACPF type Protein114728724.
- MACPF type ProteinDomains.
- MACPF type Relation100031921.
- MACPF type Situation113927383.
- MACPF type Sphere114514039.
- MACPF type State100024720.
- MACPF type Substance100019613.
- MACPF type Thing100002452.
- MACPF type Unit109465459.
- MACPF type Biomolecule.
- MACPF type Protein.
- MACPF type BiologicalObject.
- MACPF comment "The MACPF protein superfamily is named after a domain that is common to the Membrane Attack Complex proteins (MAC) of complement (C6, C7, C8α, C8β and C9) and perforin (PF). Many members of this protein family are important eukaryote pore forming toxins.The archetypal members of the family are complement C9 and perforin, both of which function in human immunity. C9 functions by punching holes in the membrane of pathogenic Gram-negative bacteria.".
- MACPF label "MACPF".
- MACPF label "MACPF".
- MACPF sameAs MACPF.
- MACPF sameAs m.02z0kvg.
- MACPF sameAs Q6714058.
- MACPF sameAs Q6714058.
- MACPF sameAs MACPF.
- MACPF wasDerivedFrom MACPF?oldid=554167489.
- MACPF depiction Paintingmacpf.jpg.
- MACPF isPrimaryTopicOf MACPF.
