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- MAD1 abstract "Mad1 is a non-essential protein in yeast which has a function in the spindle assembly checkpoint (SAC).This checkpoint monitors chromosome attachment to spindle microtubules and prevents cells from starting anaphase until the spindle is built up. The name Mad refers to the observation that mutant cells are mitotic arrest deficient (MAD) during microtubule depolymerization. Mad1 recruits the anaphase inhibitor Mad2 to unattached kinetochores and is essential for Mad2-Cdc20 complex formation in vivo but not in vitro. In vivo, Mad1 acts as a competitive inhibitorof the Mad2-Cdc20 complex. Mad1 is phosphorylated by Mps1 which then leads together with other activities to the formation of the mitotic checkpoint complex (MCC). Thereby it inhibits the activity of the anaphase-promoting complex/cyclosome (APC/C). Homolog’s of Mad1 are conserved in eukaryotes from yeast to mammals.".
- MAD1 entrezgene "8379".
- MAD1 pdb "1GO4".
- MAD1 symbol "MAD1".
- MAD1 thumbnail Tetramer_Mad1_Mad2.png?width=300.
- MAD1 uniprot "Q9Y6D9".
- MAD1 wikiPageID "26745362".
- MAD1 wikiPageRevisionID "601129037".
- MAD1 caption "Crystal structure, tetramer of Mad1-Mad2 complex, yellow and red=Mad1 monomers, palegreen= Mad2 monomers".
- MAD1 entrezgene "8379".
- MAD1 hasPhotoCollection MAD1.
- MAD1 name "Mad1".
- MAD1 pdb "1".
- MAD1 symbol "1.0".
- MAD1 uniprot "Q9Y6D9".
- MAD1 subject Category:Cell_cycle.
- MAD1 subject Category:Proteins.
- MAD1 subject Category:Saccharomyces_cerevisiae_genes.
- MAD1 type Biomolecule.
- MAD1 type Protein.
- MAD1 type BiologicalObject.
- MAD1 comment "Mad1 is a non-essential protein in yeast which has a function in the spindle assembly checkpoint (SAC).This checkpoint monitors chromosome attachment to spindle microtubules and prevents cells from starting anaphase until the spindle is built up. The name Mad refers to the observation that mutant cells are mitotic arrest deficient (MAD) during microtubule depolymerization.".
- MAD1 label "MAD1".
- MAD1 sameAs m.0cn_lpj.
- MAD1 sameAs Q6714076.
- MAD1 sameAs Q6714076.
- MAD1 wasDerivedFrom MAD1?oldid=601129037.
- MAD1 depiction Tetramer_Mad1_Mad2.png.
- MAD1 isPrimaryTopicOf MAD1.
- MAD1 name "Mad1".
