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- MAFK abstract "Transcription factor MafK is a protein that in humans is encoded by the MAFK gene.The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM]".
- MAFK entrezgene "7975".
- MAFK wikiPageID "14881786".
- MAFK wikiPageRevisionID "592338786".
- MAFK hasPhotoCollection MAFK.
- MAFK requireManualInspection "no".
- MAFK summaryText "The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions . LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 . NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase and ferrochelatase . NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein and p45 . Both subunits are members of the activator protein-1 superfamily of basic leucine zipper proteins . Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM]".
- MAFK updateCitations "yes".
- MAFK updatePage "yes".
- MAFK updateProteinBox "yes".
- MAFK updateSummary "yes".
- MAFK subject Category:Transcription_factors.
- MAFK type Abstraction100002137.
- MAFK type Beginning107290905.
- MAFK type Cause107326557.
- MAFK type Event100029378.
- MAFK type Factor107327805.
- MAFK type Happening107283608.
- MAFK type Origin107323922.
- MAFK type PsychologicalFeature100023100.
- MAFK type TranscriptionFactors.
- MAFK type YagoPermanentlyLocatedEntity.
- MAFK type Biomolecule.
- MAFK type Protein.
- MAFK type BiologicalObject.
- MAFK comment "Transcription factor MafK is a protein that in humans is encoded by the MAFK gene.The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2).".
- MAFK label "MAFK".
- MAFK sameAs m.03h08_h.
- MAFK sameAs Q6714153.
- MAFK sameAs Q6714153.
- MAFK sameAs MAFK.
- MAFK wasDerivedFrom MAFK?oldid=592338786.
- MAFK isPrimaryTopicOf MAFK.