Matches in DBpedia 2014 for { <http://dbpedia.org/resource/MAP2K3> ?p ?o. }
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- MAP2K3 abstract "Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.".
- MAP2K3 entrezgene "5606".
- MAP2K3 wikiPageID "14150975".
- MAP2K3 wikiPageRevisionID "592357001".
- MAP2K3 hasPhotoCollection MAP2K3.
- MAP2K3 requireManualInspection "no".
- MAP2K3 summaryText "The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.".
- MAP2K3 updateCitations "yes".
- MAP2K3 updatePage "yes".
- MAP2K3 updateProteinBox "yes".
- MAP2K3 updateSummary "yes".
- MAP2K3 type Biomolecule.
- MAP2K3 type Protein.
- MAP2K3 type BiologicalObject.
- MAP2K3 comment "Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK.".
- MAP2K3 label "MAP2K3".
- MAP2K3 sameAs m.03cw4zz.
- MAP2K3 sameAs Q6714345.
- MAP2K3 sameAs Q6714345.
- MAP2K3 wasDerivedFrom MAP2K3?oldid=592357001.
- MAP2K3 isPrimaryTopicOf MAP2K3.