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- MAP3K3 abstract "Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene.This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.".
- MAP3K3 entrezgene "4215".
- MAP3K3 wikiPageID "14178389".
- MAP3K3 wikiPageRevisionID "462559206".
- MAP3K3 hasPhotoCollection MAP3K3.
- MAP3K3 requireManualInspection "no".
- MAP3K3 summaryText "This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B -dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.".
- MAP3K3 updateCitations "yes".
- MAP3K3 updatePage "yes".
- MAP3K3 updateProteinBox "yes".
- MAP3K3 updateSummary "yes".
- MAP3K3 type Biomolecule.
- MAP3K3 type Protein.
- MAP3K3 type BiologicalObject.
- MAP3K3 comment "Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene.This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed.".
- MAP3K3 label "MAP3K3".
- MAP3K3 sameAs m.03cx0c5.
- MAP3K3 sameAs Q6714366.
- MAP3K3 sameAs Q6714366.
- MAP3K3 wasDerivedFrom MAP3K3?oldid=462559206.
- MAP3K3 isPrimaryTopicOf MAP3K3.