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- MAP3K7IP1 abstract "Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the MAP3K7IP1 gene.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.This protein plays an important role in skin homeostasis, wound repair, and oncogenesis.".
- MAP3K7IP1 entrezgene "10454".
- MAP3K7IP1 wikiPageID "14762792".
- MAP3K7IP1 wikiPageRevisionID "602003832".
- MAP3K7IP1 hasPhotoCollection MAP3K7IP1.
- MAP3K7IP1 requireManualInspection "no".
- MAP3K7IP1 summaryText "The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 , and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.".
- MAP3K7IP1 updateCitations "yes".
- MAP3K7IP1 updatePage "yes".
- MAP3K7IP1 updateProteinBox "yes".
- MAP3K7IP1 updateSummary "yes".
- MAP3K7IP1 type Biomolecule.
- MAP3K7IP1 type Protein.
- MAP3K7IP1 type BiologicalObject.
- MAP3K7IP1 comment "Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the MAP3K7IP1 gene.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase.".
- MAP3K7IP1 label "MAP3K7IP1".
- MAP3K7IP1 label "MAP3K7IP1".
- MAP3K7IP1 sameAs MAP3K7IP1.
- MAP3K7IP1 sameAs m.03gx446.
- MAP3K7IP1 sameAs Q5787632.
- MAP3K7IP1 sameAs Q5787632.
- MAP3K7IP1 wasDerivedFrom MAP3K7IP1?oldid=602003832.
- MAP3K7IP1 isPrimaryTopicOf MAP3K7IP1.