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- MAP3K8 abstract "Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene.This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. In mice, this gene is known as Tpl2 and it is a tumor suppressor gene whose absence contributes to the development and progression of cancer.".
- MAP3K8 entrezgene "1326".
- MAP3K8 wikiPageID "14755736".
- MAP3K8 wikiPageRevisionID "592357405".
- MAP3K8 hasPhotoCollection MAP3K8.
- MAP3K8 requireManualInspection "no".
- MAP3K8 summaryText "This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 . This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. In mice, this gene is known as Tpl2 and it is a tumor suppressor gene whose absence contributes to the development and progression of cancer.".
- MAP3K8 updateCitations "yes".
- MAP3K8 updatePage "yes".
- MAP3K8 updateProteinBox "yes".
- MAP3K8 updateSummary "yes".
- MAP3K8 type Biomolecule.
- MAP3K8 type Protein.
- MAP3K8 type BiologicalObject.
- MAP3K8 comment "Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene.This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB.".
- MAP3K8 label "MAP3K8".
- MAP3K8 sameAs MAP3K8.
- MAP3K8 sameAs m.03gwtp8.
- MAP3K8 sameAs Q6714372.
- MAP3K8 sameAs Q6714372.
- MAP3K8 sameAs MAP3K8.
- MAP3K8 sameAs TPL2.
- MAP3K8 wasDerivedFrom MAP3K8?oldid=592357405.
- MAP3K8 isPrimaryTopicOf MAP3K8.