Matches in DBpedia 2014 for { <http://dbpedia.org/resource/MAPK8> ?p ?o. }
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- MAPK8 abstract "Mitogen-activated protein kinase 8 (also known as JNK1) is an enzyme that in humans is encoded by the MAPK8 gene.The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha-induced apoptosis. This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternately spliced transcript variants encoding distinct isoforms have been reported.".
- MAPK8 entrezgene "5599".
- MAPK8 wikiPageExternalLink www.mapkinases.eu.
- MAPK8 wikiPageID "13982427".
- MAPK8 wikiPageRevisionID "592357822".
- MAPK8 hasPhotoCollection MAPK8.
- MAPK8 requireManualInspection "no".
- MAPK8 summaryText "The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha is found to be required for TNF-alpha-induced apoptosis. This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternately spliced transcript variants encoding distinct isoforms have been reported.".
- MAPK8 updateCitations "yes".
- MAPK8 updatePage "yes".
- MAPK8 updateProteinBox "yes".
- MAPK8 updateSummary "no".
- MAPK8 subject Category:EC_2.7.11.
- MAPK8 type Biomolecule.
- MAPK8 type Protein.
- MAPK8 type BiologicalObject.
- MAPK8 comment "Mitogen-activated protein kinase 8 (also known as JNK1) is an enzyme that in humans is encoded by the MAPK8 gene.The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.".
- MAPK8 label "MAPK8".
- MAPK8 label "MAPK8".
- MAPK8 sameAs MAPK8.
- MAPK8 sameAs MAPK8.
- MAPK8 sameAs m.03cq2gs.
- MAPK8 sameAs Q6714411.
- MAPK8 sameAs Q6714411.
- MAPK8 sameAs 1176.
- MAPK8 sameAs 1540.
- MAPK8 sameAs 1714.
- MAPK8 sameAs 1836.
- MAPK8 sameAs 2788.
- MAPK8 sameAs 3533.
- MAPK8 sameAs 4751.
- MAPK8 wasDerivedFrom MAPK8?oldid=592357822.
- MAPK8 isPrimaryTopicOf MAPK8.