Matches in DBpedia 2014 for { <http://dbpedia.org/resource/MBD4> ?p ?o. }
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- MBD4 abstract "Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.".
- MBD4 entrezgene "8930".
- MBD4 wikiPageID "14772672".
- MBD4 wikiPageRevisionID "605352246".
- MBD4 hasPhotoCollection MBD4.
- MBD4 requireManualInspection "no".
- MBD4 summaryText "--05-04".
- MBD4 updateCitations "yes".
- MBD4 updatePage "yes".
- MBD4 updateProteinBox "yes".
- MBD4 updateSummary "yes".
- MBD4 type Biomolecule.
- MBD4 type Protein.
- MBD4 type BiologicalObject.
- MBD4 comment "Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA.".
- MBD4 label "MBD4".
- MBD4 sameAs m.03gxhmt.
- MBD4 sameAs Q6714712.
- MBD4 sameAs Q6714712.
- MBD4 wasDerivedFrom MBD4?oldid=605352246.
- MBD4 isPrimaryTopicOf MBD4.