Matches in DBpedia 2014 for { <http://dbpedia.org/resource/MCM4> ?p ?o. }
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- MCM4 abstract "DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.".
- MCM4 entrezgene "4173".
- MCM4 wikiPageID "14179777".
- MCM4 wikiPageRevisionID "462306975".
- MCM4 hasPhotoCollection MCM4.
- MCM4 requireManualInspection "no".
- MCM4 summaryText "The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.".
- MCM4 updateCitations "yes".
- MCM4 updatePage "yes".
- MCM4 updateProteinBox "yes".
- MCM4 updateSummary "yes".
- MCM4 type Biomolecule.
- MCM4 type Protein.
- MCM4 type BiologicalObject.
- MCM4 comment "DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.".
- MCM4 label "MCM4".
- MCM4 sameAs m.03cx1lc.
- MCM4 sameAs Q6714937.
- MCM4 sameAs Q6714937.
- MCM4 wasDerivedFrom MCM4?oldid=462306975.
- MCM4 isPrimaryTopicOf MCM4.