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- MID1 abstract "Midline-1 is a protein that in humans is encoded by the MID1 gene.The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Several different transcript variants are generated by alternate splicing; however, the full length nature of two variants has not been determined.".
- MID1 entrezgene "4281".
- MID1 wikiPageExternalLink br.fcgi?book=gene&part=opitz.
- MID1 wikiPageID "14760097".
- MID1 wikiPageRevisionID "602023349".
- MID1 hasPhotoCollection MID1.
- MID1 requireManualInspection "no".
- MID1 summaryText "The protein encoded by this gene is a member of the tripartite motif family, also known as the 'RING-B box-coiled coil' subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Several different transcript variants are generated by alternate splicing; however, the full length nature of two variants has not been determined.".
- MID1 updateCitations "yes".
- MID1 updatePage "yes".
- MID1 updateProteinBox "yes".
- MID1 updateSummary "yes".
- MID1 type Biomolecule.
- MID1 type Protein.
- MID1 type BiologicalObject.
- MID1 comment "Midline-1 is a protein that in humans is encoded by the MID1 gene.The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm.".
- MID1 label "MID1".
- MID1 sameAs m.03gw__s.
- MID1 sameAs Q6715985.
- MID1 sameAs Q6715985.
- MID1 sameAs MID1.
- MID1 wasDerivedFrom MID1?oldid=602023349.
- MID1 isPrimaryTopicOf MID1.