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- MTA2 abstract "Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.".
- MTA2 entrezgene "9219".
- MTA2 wikiPageID "14775326".
- MTA2 wikiPageRevisionID "592596696".
- MTA2 hasPhotoCollection MTA2.
- MTA2 requireManualInspection "no".
- MTA2 summaryText "This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.".
- MTA2 updateCitations "yes".
- MTA2 updatePage "yes".
- MTA2 updateProteinBox "yes".
- MTA2 updateSummary "yes".
- MTA2 subject Category:Transcription_factors.
- MTA2 type Biomolecule.
- MTA2 type Protein.
- MTA2 type BiologicalObject.
- MTA2 comment "Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues.".
- MTA2 label "MTA2".
- MTA2 label "MTA2".
- MTA2 sameAs MTA2.
- MTA2 sameAs m.03gxl_h.
- MTA2 sameAs Q6718403.
- MTA2 sameAs Q6718403.
- MTA2 wasDerivedFrom MTA2?oldid=592596696.
- MTA2 isPrimaryTopicOf MTA2.