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- Macrophage_inflammatory_protein abstract "Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β that are now officially named CCL3 and CCL4, respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They are crucial for immune responses towards infection and inflammation. They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-6 and TNF-α from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.They are produced by many cells, particularly macrophages, dendritic cells, and lymphocytes. MIP-1 are best known for their chemotactic and proinflammatory effects but can also promote homoeostasis. Biophysical analyses and mathematical modelling has shown that MIP-1 reversibly forms a polydisperse distribution of rod-shaped polymers in solution. Polymerization buries receptor-binding sites of MIP-1, thus depolymerization mutations enhance MIP-1 to arrest monocytes onto activated human endothelium.".
- Macrophage_inflammatory_protein arm "q".
- Macrophage_inflammatory_protein band "12".
- Macrophage_inflammatory_protein band "21".
- Macrophage_inflammatory_protein chromosome "17".
- Macrophage_inflammatory_protein entrezgene "6348".
- Macrophage_inflammatory_protein entrezgene "6351".
- Macrophage_inflammatory_protein hgncid "10627".
- Macrophage_inflammatory_protein hgncid "10630".
- Macrophage_inflammatory_protein locusSupplementaryData "-q23".
- Macrophage_inflammatory_protein omim "182283".
- Macrophage_inflammatory_protein omim "182284".
- Macrophage_inflammatory_protein pdb "1B50".
- Macrophage_inflammatory_protein pdb "1HUM".
- Macrophage_inflammatory_protein refseq "NM_002983".
- Macrophage_inflammatory_protein refseq "NM_002984".
- Macrophage_inflammatory_protein symbol "CCL3".
- Macrophage_inflammatory_protein symbol "CCL4".
- Macrophage_inflammatory_protein symbol "SCYA3, MIP-1α".
- Macrophage_inflammatory_protein symbol "SCYA4, MIP-1β, LAG1".
- Macrophage_inflammatory_protein thumbnail 1b53.png?width=300.
- Macrophage_inflammatory_protein uniprot "P10147".
- Macrophage_inflammatory_protein uniprot "P13236".
- Macrophage_inflammatory_protein wikiPageExternalLink searchResults.html?display=both&term=P10147.
- Macrophage_inflammatory_protein wikiPageExternalLink searchResults.html?display=both&term=P13236.
- Macrophage_inflammatory_protein wikiPageID "5573084".
- Macrophage_inflammatory_protein wikiPageRevisionID "592335232".
- Macrophage_inflammatory_protein altsymbols "SCYA3, MIP-1α".
- Macrophage_inflammatory_protein altsymbols "SCYA4, MIP-1β, LAG1".
- Macrophage_inflammatory_protein arm "q".
- Macrophage_inflammatory_protein band "12".
- Macrophage_inflammatory_protein band "21".
- Macrophage_inflammatory_protein caption "Human Mip-1α dimer D26A mutant. PDB . Disulfide bonds highlighted.".
- Macrophage_inflammatory_protein caption "Human Mip-1β dimer. PDB . Disulfide bonds highlighted.".
- Macrophage_inflammatory_protein chromosome "17".
- Macrophage_inflammatory_protein entrezgene "6348".
- Macrophage_inflammatory_protein entrezgene "6351".
- Macrophage_inflammatory_protein hasPhotoCollection Macrophage_inflammatory_protein.
- Macrophage_inflammatory_protein hgncid "10627".
- Macrophage_inflammatory_protein hgncid "10630".
- Macrophage_inflammatory_protein locussupplementarydata "-q23".
- Macrophage_inflammatory_protein name CCL3.
- Macrophage_inflammatory_protein name CCL4.
- Macrophage_inflammatory_protein omim "182283".
- Macrophage_inflammatory_protein omim "182284".
- Macrophage_inflammatory_protein pdb "1".
- Macrophage_inflammatory_protein pdbSupplemental searchResults.html?display=both&term=P10147.
- Macrophage_inflammatory_protein pdbSupplemental searchResults.html?display=both&term=P13236.
- Macrophage_inflammatory_protein refseq "NM_002983".
- Macrophage_inflammatory_protein refseq "NM_002984".
- Macrophage_inflammatory_protein symbol CCL3.
- Macrophage_inflammatory_protein symbol "CCL4".
- Macrophage_inflammatory_protein uniprot "P10147".
- Macrophage_inflammatory_protein uniprot "P13236".
- Macrophage_inflammatory_protein subject Category:Cytokines.
- Macrophage_inflammatory_protein type Abstraction100002137.
- Macrophage_inflammatory_protein type Chemical114806838.
- Macrophage_inflammatory_protein type Compound114818238.
- Macrophage_inflammatory_protein type Cytokine114828193.
- Macrophage_inflammatory_protein type Cytokines.
- Macrophage_inflammatory_protein type Macromolecule114944888.
- Macrophage_inflammatory_protein type Material114580897.
- Macrophage_inflammatory_protein type Matter100020827.
- Macrophage_inflammatory_protein type Molecule114682133.
- Macrophage_inflammatory_protein type OrganicCompound114727670.
- Macrophage_inflammatory_protein type Part113809207.
- Macrophage_inflammatory_protein type PhysicalEntity100001930.
- Macrophage_inflammatory_protein type Protein114728724.
- Macrophage_inflammatory_protein type Relation100031921.
- Macrophage_inflammatory_protein type Substance100019613.
- Macrophage_inflammatory_protein type Thing100002452.
- Macrophage_inflammatory_protein type Unit109465459.
- Macrophage_inflammatory_protein type Biomolecule.
- Macrophage_inflammatory_protein type Protein.
- Macrophage_inflammatory_protein type ProteinMolecule.
- Macrophage_inflammatory_protein type BiologicalObject.
- Macrophage_inflammatory_protein comment "Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β that are now officially named CCL3 and CCL4, respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They are crucial for immune responses towards infection and inflammation.".
- Macrophage_inflammatory_protein label "Macrophage inflammatory protein".
- Macrophage_inflammatory_protein sameAs m.0dt681.
- Macrophage_inflammatory_protein sameAs Q6725509.
- Macrophage_inflammatory_protein sameAs Q6725509.
- Macrophage_inflammatory_protein sameAs Macrophage_inflammatory_protein.
- Macrophage_inflammatory_protein wasDerivedFrom Macrophage_inflammatory_protein?oldid=592335232.
- Macrophage_inflammatory_protein depiction 1b53.png.
- Macrophage_inflammatory_protein isPrimaryTopicOf Macrophage_inflammatory_protein.
- Macrophage_inflammatory_protein name "chemokine (C-C motif) ligand 3".
- Macrophage_inflammatory_protein name "chemokine (C-C motif) ligand 4".