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- Mannomustine abstract "Mannomustine (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from the group of nitrogen mustards. It was first synthesized and characterized in 1957 by Vargha et al.The mechanism of antineoplastic activity of mannomustine, like for all other alkylating agents, lies in its ability to alkylate DNA guanine nucleobases and, thus, to prevent uncoupling of DNA strands, which is a required step for any cell to divide.Mannomustine was, at the time of its creation as a drug, claimed to be considerably less toxic than mechlorethamine. For example, the LD50 in rats, for intravenous mannomustine administration route, is claimed to be about 56 mg/kg.".
- Mannomustine atcPrefix "L01".
- Mannomustine casNumber "551-74-6".
- Mannomustine iupacName "(2-chloroethyl)({6-[(2-chloroethyl)amino]-2,3,4,5-tetrahydroxyhexyl})amine".
- Mannomustine thumbnail Mannomustine_chemical_structure.gif?width=300.
- Mannomustine wikiPageID "41725980".
- Mannomustine wikiPageRevisionID "598310671".
- Mannomustine atcPrefix "L01".
- Mannomustine c "10".
- Mannomustine casNumber "551".
- Mannomustine cl "4".
- Mannomustine dependencyLiability "not capable to cause dependency".
- Mannomustine excretion Kidney.
- Mannomustine h "24".
- Mannomustine inchi "1".
- Mannomustine inchikey "MQXVYODZCMMZEM-UHFFFAOYSA-N".
- Mannomustine iupacName "amine".
- Mannomustine legalStatus "Rx-only".
- Mannomustine metabolism Liver.
- Mannomustine molecularWeight "378.12".
- Mannomustine n "2".
- Mannomustine o "4".
- Mannomustine pregnancyAu "D".
- Mannomustine pregnancyCategory "D".
- Mannomustine pregnancyUs "D".
- Mannomustine routesOfAdministration Intramuscular_injection.
- Mannomustine smiles "OCCCCCNCCCl".
- Mannomustine specificRotation "[a]D20 +18.46°".
- Mannomustine stdinchi "1".
- Mannomustine stdinchikey "MQXVYODZCMMZEM-UHFFFAOYSA-N".
- Mannomustine tradename "Degranol".
- Mannomustine watchedfields "changed".
- Mannomustine subject Category:Nitrogen_mustards.
- Mannomustine type Drug.
- Mannomustine type FunctionalSubstance.
- Mannomustine comment "Mannomustine (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from the group of nitrogen mustards.".
- Mannomustine label "Mannomustine".
- Mannomustine label "Манномустин".
- Mannomustine sameAs m.0_fsrg2.
- Mannomustine sameAs Q15640018.
- Mannomustine sameAs Q15640018.
- Mannomustine wasDerivedFrom Mannomustine?oldid=598310671.
- Mannomustine depiction Mannomustine_chemical_structure.gif.
- Mannomustine isPrimaryTopicOf Mannomustine.
