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- Maprotiline abstract "Maprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake.It exerts strong blocking effect at H1 receptors, moderate at 5-HT2 and alpha1 and weak blocking effect at D2 and mACh postsynaptic receptors.It exerts blocking effects at the following postsynaptic receptors: Strong : H1 Moderate : 5-HT2, alpha1 Weak : D2, mAChThe pharmacologic profile of Maprotiline explains its antidepressant, sedative, anxiolytic, and sympathomimetic activities. In accordance to the pharmacological characteristics it is used in the treatment of depression, such as depression associated with agitation or anxiety. Additionally, it shows a strong antagonism against Reserpine-induced effects in animal studies, as do the other 'classical' antidepressants. Although Maprotiline behaves in most regards as a 'first generation antidepressant' it is commonly referred to as 'second generation antidepressant'.".
- Maprotiline atcPrefix "N06".
- Maprotiline atcSuffix "AA21".
- Maprotiline bioavailability "66.0".
- Maprotiline casNumber "10262-69-8".
- Maprotiline drugbank "DB00934".
- Maprotiline fdaUniiCode "2U1W68TROF".
- Maprotiline iupacName "N-Methyl-9,10-ethanoanthracene-9(10H)-propanamine".
- Maprotiline pubchem "4011".
- Maprotiline thumbnail Maprotiline.svg?width=300.
- Maprotiline wikiPageExternalLink AliefAus.php?pnumm=660767574489&pname=Maprotiline.
- Maprotiline wikiPageExternalLink MonographieTxt.aspx?lang=de&MonType=fi.
- Maprotiline wikiPageExternalLink p30-l04.html.
- Maprotiline wikiPageExternalLink pharmclips2.cgi?keyword=%20Ludiomil%AE.
- Maprotiline wikiPageID "287248".
- Maprotiline wikiPageRevisionID "599221247".
- Maprotiline atcPrefix "N06".
- Maprotiline atcSuffix "AA21".
- Maprotiline bioavailability "66".
- Maprotiline c "20".
- Maprotiline casNumber "10262".
- Maprotiline chembl "21731".
- Maprotiline chemspiderid "3871".
- Maprotiline drugbank "DB00934".
- Maprotiline eliminationHalfLife "-208800.0".
- Maprotiline excretion "biliar and urine as gluconurides, 3 to 4% as unchanged drug".
- Maprotiline h "23".
- Maprotiline hasPhotoCollection Maprotiline.
- Maprotiline image "Maprotiline3Dan.gif".
- Maprotiline inchi "1".
- Maprotiline iupacName "N-Methyl-9,10-ethanoanthracene-9-propanamine".
- Maprotiline iupharLigand "2402".
- Maprotiline kegg "D02566".
- Maprotiline legalAu "S4".
- Maprotiline legalUs "Rx-only".
- Maprotiline medlineplus "a682158".
- Maprotiline metabolism "hepatic".
- Maprotiline molecularWeight "277.403".
- Maprotiline n "1".
- Maprotiline pregnancyUs "B3".
- Maprotiline proteinBound "88.0".
- Maprotiline pubchem "4011".
- Maprotiline routesOfAdministration "oral, intramuscular, intravenous".
- Maprotiline smiles "c1ccc3cC4c2ccccc2C3CCCNC".
- Maprotiline stdinchi "1".
- Maprotiline stdinchikey "QSLMDECMDJKHMQ-UHFFFAOYSA-N".
- Maprotiline unii "2".
- Maprotiline verifiedrevid "477169275".
- Maprotiline watchedfields "changed".
- Maprotiline width "200".
- Maprotiline width "250".
- Maprotiline subject Category:Amines.
- Maprotiline subject Category:Anthracenes.
- Maprotiline subject Category:Norepinephrine_reuptake_inhibitors.
- Maprotiline subject Category:Tetracyclic_antidepressants.
- Maprotiline type Agent114778436.
- Maprotiline type Antidepressant102718811.
- Maprotiline type CausalAgent100007347.
- Maprotiline type Drug103247620.
- Maprotiline type Inhibitor114724436.
- Maprotiline type Matter100020827.
- Maprotiline type Medicine103740161.
- Maprotiline type NorepinephrineReuptakeInhibitors.
- Maprotiline type PhysicalEntity100001930.
- Maprotiline type Substance100020090.
- Maprotiline type TetracyclicAntidepressants.
- Maprotiline type Drug.
- Maprotiline type DrugProduct.
- Maprotiline type FunctionalSubstance.
- Maprotiline comment "Maprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring.".
- Maprotiline label "Maprotilin".
- Maprotiline label "Maprotilina".
- Maprotiline label "Maprotiline".
- Maprotiline label "Maprotylina".
- Maprotiline label "Мапротилин".
- Maprotiline label "マプロチリン".
- Maprotiline sameAs Maprotilin.
- Maprotiline sameAs マプロチリン.
- Maprotiline sameAs Maprotylina.
- Maprotiline sameAs Maprotilina.
- Maprotiline sameAs m.01q5sf.
- Maprotiline sameAs Q418361.
- Maprotiline sameAs Q418361.
- Maprotiline sameAs Maprotiline.
- Maprotiline sameAs DB00934.
- Maprotiline sameAs 4011.
- Maprotiline sameAs Maprotiline.
- Maprotiline wasDerivedFrom Maprotiline?oldid=599221247.
- Maprotiline depiction Maprotiline.svg.
- Maprotiline isPrimaryTopicOf Maprotiline.
