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- Megaloblastic_anemia abstract "Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage. This leads to continuing cell growth without division, which presents as macrocytosis.Megaloblastic anemia has a rather slow onset, especially when compared to that of other anemias.The defect in red cell DNA synthesis is most often due to hypovitaminosis, specifically a deficiency of vitamin B12 and/or folic acid. Vitamin B12 deficiency alone will not cause the syndrome in the presence of sufficient folate, for the mechanism is loss of B12 dependent folate recycling, followed by folate-deficiency loss of nucleic acid synthesis (specifically thymine), leading to defects in DNA synthesis. Folic acid supplementation in the absence of vitamin B12 prevents this type of anemia (although other vitamin B12-specific pathologies continue). Loss of micronutrients may also be a cause. Copper deficiency resulting from zinc excess from unusually high oral consumption of zinc containing denture fixation creams has been found to be a cause.Megaloblastic anemia not due to hypovitaminosis may be caused by antimetabolites that poison DNA production directly, such as some chemotherapeutic or antimicrobial agents (for example azathioprine or trimethoprim).The pathological state of megaloblastosis is characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow and also by hypersegmented neutrophils (those exhibiting five or more nuclear lobes ("segments"), with up to four lobes being normal). These hypersegmented neutrophils are found in the "peripheral blood" (i.e., a diagnostic smear of a blood-sample taken from the circulation).".
- Megaloblastic_anemia diseasesdb "29507".
- Megaloblastic_anemia emedicineSubject "med".
- Megaloblastic_anemia emedicineTopic "1420".
- Megaloblastic_anemia icd10 "D51.1, D52.0, D53.1".
- Megaloblastic_anemia icd9 "281".
- Megaloblastic_anemia medlineplus "000567".
- Megaloblastic_anemia meshId "D000749".
- Megaloblastic_anemia thumbnail Hypersegmented_neutrophil.png?width=300.
- Megaloblastic_anemia wikiPageExternalLink br.fcgi?book=gene&part=trma.
- Megaloblastic_anemia wikiPageExternalLink www.rareanemias.webs.com.
- Megaloblastic_anemia wikiPageID "1407166".
- Megaloblastic_anemia wikiPageRevisionID "598767661".
- Megaloblastic_anemia caption "Peripheral blood smear showing hypersegmented neutrophils, characteristic of megaloblastic anemia.".
- Megaloblastic_anemia diseasesdb "29507".
- Megaloblastic_anemia emedicinesubj "med".
- Megaloblastic_anemia emedicinetopic "1420".
- Megaloblastic_anemia hasPhotoCollection Megaloblastic_anemia.
- Megaloblastic_anemia icd "281".
- Megaloblastic_anemia icd "D51.1, D52.0, D53.1".
- Megaloblastic_anemia medlineplus "567".
- Megaloblastic_anemia meshid "D000749".
- Megaloblastic_anemia name "Megaloblastic anemia".
- Megaloblastic_anemia wordnet_type synset-disease-noun-1.
- Megaloblastic_anemia subject Category:Hematopathology.
- Megaloblastic_anemia subject Category:Nutritional_anemias.
- Megaloblastic_anemia type Disease.
- Megaloblastic_anemia type AilmentCondition.
- Megaloblastic_anemia type Situation.
- Megaloblastic_anemia comment "Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage.".
- Megaloblastic_anemia label "Anemia megaloblastica".
- Megaloblastic_anemia label "Anemia megaloblástica".
- Megaloblastic_anemia label "Anemia megaloblástica".
- Megaloblastic_anemia label "Megaloblastic anemia".
- Megaloblastic_anemia label "Niedokrwistość megaloblastyczna".
- Megaloblastic_anemia label "Пернициозная анемия".
- Megaloblastic_anemia label "فقر الدم الضخم الأرومات".
- Megaloblastic_anemia label "巨赤芽球性貧血".
- Megaloblastic_anemia sameAs Anemia_megaloblástica.
- Megaloblastic_anemia sameAs Anemia_megaloblastica.
- Megaloblastic_anemia sameAs 巨赤芽球性貧血.
- Megaloblastic_anemia sameAs Niedokrwistość_megaloblastyczna.
- Megaloblastic_anemia sameAs Anemia_megaloblástica.
- Megaloblastic_anemia sameAs m.04_235.
- Megaloblastic_anemia sameAs Q10832211.
- Megaloblastic_anemia sameAs Q10832211.
- Megaloblastic_anemia sameAs 736.
- Megaloblastic_anemia sameAs C0002888.
- Megaloblastic_anemia wasDerivedFrom Megaloblastic_anemia?oldid=598767661.
- Megaloblastic_anemia depiction Hypersegmented_neutrophil.png.
- Megaloblastic_anemia isPrimaryTopicOf Megaloblastic_anemia.
- Megaloblastic_anemia name "Megaloblastic anemia".
