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- Merkel_cell_polyomavirus abstract "Merkel cell polyomavirus (MCV or MCPyV) was first described in January 2008. It was the first example of a human viral pathogen discovered using unbiased metagenomic next-generation sequencing with a technique called digital transcriptomic subtraction. MCV is one of seven known human tumor viruses. It is suspected to cause the majority of cases of Merkel cell carcinoma, a rare but aggressive form of skin cancer. Approximately 80% of Merkel cell carcinoma (MCC) tumors have been found to be infected with MCV. MCV appears to be a common—if not universal—infection of older children and adults. It is found in respiratory secretions suggesting that it may be transmitted by a respiratory route. But it also can be found shedding from healthy skin, and in gastrointestinal tract tissues and elsewhere, and so its precise mode of transmission remains unknown. Most MCV viruses found in MCC tumors, however, have at least two mutations that render the virus nontransmissible: 1) The virus is integrated into the host genome in a monoclonal fashion and 2) The viral T antigen has truncation mutations that leave the T antigen unable to initiate DNA replication needed to propagate the virus.Evidence that MCV is the cause for most MCC tumors comes from studies in which T antigen oncoproteins from the virus are inhibited. Knock down of these viral proteins causes cells from MCV-positive MCC tumors to die whereas there is no effect on cells from tumors that are uninfected with the virus. This indicates that MCV is necessary to maintain the virus-positive tumor cells. Further, clonal pattern of MCV insertions into MCC cell genomes indicates that the virus was present in the Merkel cell before it underwent cancerous transformation. The IARC has recently classified MCV as a class 2A carcinogen.".
- Merkel_cell_polyomavirus colourName "violet".
- Merkel_cell_polyomavirus family Polyomaviridae.
- Merkel_cell_polyomavirus genus Orthopolyomavirus.
- Merkel_cell_polyomavirus thumbnail Polyomavirustree.jpg?width=300.
- Merkel_cell_polyomavirus wikiPageExternalLink pathogen.html.
- Merkel_cell_polyomavirus wikiPageExternalLink dts.html.
- Merkel_cell_polyomavirus wikiPageExternalLink mcvrsch.html.
- Merkel_cell_polyomavirus wikiPageID "16814276".
- Merkel_cell_polyomavirus wikiPageRevisionID "600823100".
- Merkel_cell_polyomavirus color "violet".
- Merkel_cell_polyomavirus familia "Polyomaviridae".
- Merkel_cell_polyomavirus genus "Orthopolyomavirus".
- Merkel_cell_polyomavirus hasPhotoCollection Merkel_cell_polyomavirus.
- Merkel_cell_polyomavirus name "Merkel cell polyomavirus".
- Merkel_cell_polyomavirus ordo "Unassigned".
- Merkel_cell_polyomavirus species "Merkel cell polyomavirus".
- Merkel_cell_polyomavirus virusGroup "i".
- Merkel_cell_polyomavirus subject Category:Polyomaviruses.
- Merkel_cell_polyomavirus type Species.
- Merkel_cell_polyomavirus type Organism.
- Merkel_cell_polyomavirus comment "Merkel cell polyomavirus (MCV or MCPyV) was first described in January 2008. It was the first example of a human viral pathogen discovered using unbiased metagenomic next-generation sequencing with a technique called digital transcriptomic subtraction. MCV is one of seven known human tumor viruses. It is suspected to cause the majority of cases of Merkel cell carcinoma, a rare but aggressive form of skin cancer.".
- Merkel_cell_polyomavirus label "Merkel cell polyomavirus".
- Merkel_cell_polyomavirus label "Merkelcelpolyomavirus".
- Merkel_cell_polyomavirus label "Merkelzell-Polyomavirus".
- Merkel_cell_polyomavirus sameAs Merkelzell-Polyomavirus.
- Merkel_cell_polyomavirus sameAs Merkelcelpolyomavirus.
- Merkel_cell_polyomavirus sameAs m.04075_4.
- Merkel_cell_polyomavirus sameAs Q1921796.
- Merkel_cell_polyomavirus sameAs Q1921796.
- Merkel_cell_polyomavirus wasDerivedFrom Merkel_cell_polyomavirus?oldid=600823100.
- Merkel_cell_polyomavirus depiction Polyomavirustree.jpg.
- Merkel_cell_polyomavirus isPrimaryTopicOf Merkel_cell_polyomavirus.
- Merkel_cell_polyomavirus name "Merkel cell polyomavirus".
