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- Metaxalone abstract "Not to be confused with Metolazone, a diuretic.Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. Skelaxin is available in an 800 mg scored tablet. Possible side effects include nausea, vomiting, drowsiness and CNS side effects, such as dizziness, headache, and irritability.Metaxalone exhibits increased bioavailability when taken with food. Specifically, in one study, compared to fasted conditions, the presence of food at the time of drug administration increased Cmax by 77.5%, AUC0-t by 23.5%, and AUC0-∞ by 15.4%. Thus, based on the information in the labeling, patients receiving metaxalone therapy are directed to take metaxalone with food, and are informed that taking metaxalone with food results in an increase in the oral bioavailability of metaxalone compared to taking metaxalone without food.The metabolism of metaxalone involves the liver cytochrome P450 system. Based on the information in the labeling, patients receiving metaxalone therapy and physicians prescribing metaxalone are directed to take precaution when coadministering it with other medications involving the P450 system.Because of potential for side effects, this drug is on the list for high risk medications in the elderly.".
- Metaxalone atcPrefix "none".
- Metaxalone casNumber "1665-48-1".
- Metaxalone drugbank "DB00660".
- Metaxalone fdaUniiCode "1NMA9J598Y".
- Metaxalone iupacName "5-[(3,5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one".
- Metaxalone pubchem "15459".
- Metaxalone thumbnail Metaxalone.svg?width=300.
- Metaxalone wikiPageExternalLink Drugs_Avoided_Elderly.pdf.
- Metaxalone wikiPageExternalLink www.skelaxin.com.
- Metaxalone wikiPageID "3127074".
- Metaxalone wikiPageRevisionID "592478997".
- Metaxalone atcPrefix "none".
- Metaxalone bioavailability "Unknown".
- Metaxalone c "12".
- Metaxalone casNumber "1665".
- Metaxalone chembl "1079604".
- Metaxalone chemspiderid "14709".
- Metaxalone drugbank "DB00660".
- Metaxalone eliminationHalfLife "33120.0".
- Metaxalone excretion Kidney.
- Metaxalone h "15".
- Metaxalone hasPhotoCollection Metaxalone.
- Metaxalone inchi "1".
- Metaxalone inchikey "IMWZZHHPURKASS-UHFFFAOYAR".
- Metaxalone iupacName "5".
- Metaxalone kegg "D00773".
- Metaxalone legalUs "Rx-only".
- Metaxalone medlineplus "a682010".
- Metaxalone metabolism Liver.
- Metaxalone molecularWeight "221.252".
- Metaxalone n "1".
- Metaxalone o "3".
- Metaxalone pregnancyUs "C".
- Metaxalone pubchem "15459".
- Metaxalone routesOfAdministration "Oral".
- Metaxalone smiles "O=C2OCCN2".
- Metaxalone stdinchi "1".
- Metaxalone stdinchikey "IMWZZHHPURKASS-UHFFFAOYSA-N".
- Metaxalone tradename "Skelaxin".
- Metaxalone unii "1".
- Metaxalone verifiedrevid "458442143".
- Metaxalone width "200".
- Metaxalone subject Category:Carbamates.
- Metaxalone subject Category:Muscle_relaxants.
- Metaxalone subject Category:Oxazolidines.
- Metaxalone subject Category:Phenol_ethers.
- Metaxalone type Abstraction100002137.
- Metaxalone type Carbamate114792281.
- Metaxalone type Carbamates.
- Metaxalone type Chemical114806838.
- Metaxalone type Compound114818238.
- Metaxalone type Element114840755.
- Metaxalone type Material114580897.
- Metaxalone type Matter100020827.
- Metaxalone type Part113809207.
- Metaxalone type PhenolEthers.
- Metaxalone type PhysicalEntity100001930.
- Metaxalone type Quintessence114847103.
- Metaxalone type Relation100031921.
- Metaxalone type Salt115010703.
- Metaxalone type Substance100019613.
- Metaxalone type Drug.
- Metaxalone type DrugProduct.
- Metaxalone type FunctionalSubstance.
- Metaxalone comment "Not to be confused with Metolazone, a diuretic.Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.".
- Metaxalone label "Metaxalone".
- Metaxalone sameAs m.08t5w8.
- Metaxalone sameAs Q6823309.
- Metaxalone sameAs Q6823309.
- Metaxalone sameAs Metaxalone.
- Metaxalone sameAs DB00660.
- Metaxalone sameAs Metaxalone.
- Metaxalone wasDerivedFrom Metaxalone?oldid=592478997.
- Metaxalone depiction Metaxalone.svg.
- Metaxalone isPrimaryTopicOf Metaxalone.
