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- Microsatellite_instability abstract "Microsatellite instability (MSI) is the condition of genetic hypermutability that results from impaired DNA Mismatch Repair (MMR). In other words, MSI is the phenotypic evidence that MMR is not functioning normally. DNA MMR corrects errors that spontaneously occur during DNA replication like single base mismatches or short insertions and deletions. The proteins involved in MMR form a complex that binds to the mismatch, identifies the correct strand of DNA, then subsequently excises the error and repairs the mismatch. Cells with abnormally functioning MMR tend to accumulate errors rather than correcting those errors. As a result, gene sequences are not preserved faithfully through DNA replication, and novel Microsatellites fragments are created. Microsatellite instability is detected by PCR based assays that reveal these novel microsatellites.Microsatellites are repeated sequences of DNA. These sequences can be made of repeating units of 1-6 base pairs in length. Although the length of these microsatellites is highly variable from person to person (part of DNA "fingerprint"), each individual has microsatellites of a set length. The most common microsatellite in humans is a dinucleotide repeat of CA, which occurs tens of thousands of times across the genome. Microsatellites are also known as simple sequence repeats (SSRs).".
- Microsatellite_instability thumbnail Tumour-infiltrating_lymphocytes_-_2_--_extremely_high_mag.jpg?width=300.
- Microsatellite_instability wikiPageExternalLink 12119215.
- Microsatellite_instability wikiPageID "7413343".
- Microsatellite_instability wikiPageRevisionID "606794696".
- Microsatellite_instability hasPhotoCollection Microsatellite_instability.
- Microsatellite_instability type Abstraction100002137.
- Microsatellite_instability type Arrangement107938773.
- Microsatellite_instability type Group100031264.
- Microsatellite_instability type Ordering108456993.
- Microsatellite_instability type RepetitiveDNASequences.
- Microsatellite_instability type Sequence108459252.
- Microsatellite_instability type Series108457976.
- Microsatellite_instability comment "Microsatellite instability (MSI) is the condition of genetic hypermutability that results from impaired DNA Mismatch Repair (MMR). In other words, MSI is the phenotypic evidence that MMR is not functioning normally. DNA MMR corrects errors that spontaneously occur during DNA replication like single base mismatches or short insertions and deletions.".
- Microsatellite_instability label "Microsatellite instability".
- Microsatellite_instability label "Mikrosatelliteninstabilität".
- Microsatellite_instability label "Niestabilność mikrosatelitarna".
- Microsatellite_instability sameAs Mikrosatelliteninstabilität.
- Microsatellite_instability sameAs Niestabilność_mikrosatelitarna.
- Microsatellite_instability sameAs m.0260x86.
- Microsatellite_instability sameAs Q488212.
- Microsatellite_instability sameAs Q488212.
- Microsatellite_instability sameAs Microsatellite_instability.
- Microsatellite_instability wasDerivedFrom Microsatellite_instability?oldid=606794696.
- Microsatellite_instability depiction Tumour-infiltrating_lymphocytes_-_2_--_extremely_high_mag.jpg.
- Microsatellite_instability isPrimaryTopicOf Microsatellite_instability.
