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- Mitomycin abstract "The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. One of these compounds, mitomycin C, finds use as a chemotherapeutic agent by virtue of its antitumour antibiotic activity. It is given intravenously to treat upper gastro-intestinal (e.g. esophageal carcinoma), anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause lung fibrosis and renal damage.Mitomycin C has also been used topically rather than intravenously in several areas. The first is cancers, particularly bladder cancers and intraperitoneal tumours. It is now well known that a single instillation of this agent within 6 hours of bladder tumor resection can prevent recurrence. The second is in eye surgery where mitomycin C 0.02% is applied topically to prevent scarring during glaucoma filtering surgery and to prevent haze after PRK or superlasik; mitomycin C has also been shown to reduce fibrosis in strabismus surgery. The third is in esophageal and tracheal stenosis where application of mitomycin C onto the mucosa immediately following dilatation will decrease re-stenosis by decreasing the production of fibroblasts and scar tissue.".
- Mitomycin iupacName "{11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate".
- Mitomycin thumbnail Mitomycin.svg?width=300.
- Mitomycin wikiPageExternalLink S1074-5521(99)80040-4.
- Mitomycin wikiPageExternalLink ja015646l.
- Mitomycin wikiPageExternalLink ja00259a046.
- Mitomycin wikiPageID "2951818".
- Mitomycin wikiPageRevisionID "604820077".
- Mitomycin hasPhotoCollection Mitomycin.
- Mitomycin imagefile "Mitomycin ball-and-stick.png".
- Mitomycin imagefile "Mitomycin.svg".
- Mitomycin imagename "Stereo wireframe model of -mitomycin".
- Mitomycin iupacname "{11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1,11-dien-8-yl}methyl carbamate".
- Mitomycin othernames "Mitomycin C".
- Mitomycin pin "[6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate".
- Mitomycin verifiedrevid "446300024".
- Mitomycin watchedfields "changed".
- Mitomycin subject Category:Aziridines.
- Mitomycin subject Category:Carbamates.
- Mitomycin subject Category:DNA_replication_inhibitors.
- Mitomycin subject Category:Ethers.
- Mitomycin subject Category:IARC_Group_2B_carcinogens.
- Mitomycin subject Category:Quinones.
- Mitomycin type ChemicalCompound.
- Mitomycin type ChemicalSubstance.
- Mitomycin type DrugProduct.
- Mitomycin type ChemicalObject.
- Mitomycin type Thing.
- Mitomycin comment "The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. One of these compounds, mitomycin C, finds use as a chemotherapeutic agent by virtue of its antitumour antibiotic activity. It is given intravenously to treat upper gastro-intestinal (e.g. esophageal carcinoma), anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours.".
- Mitomycin label "Mitomicina".
- Mitomycin label "Mitomicina".
- Mitomycin label "Mitomycin".
- Mitomycin label "Mitomycin".
- Mitomycin label "Mitomycine C".
- Mitomycin label "Mitomycyna".
- Mitomycin label "Митомицин C".
- Mitomycin label "マイトマイシンC".
- Mitomycin label "丝裂霉素".
- Mitomycin sameAs Mitomycin.
- Mitomycin sameAs Mitomicina.
- Mitomycin sameAs Mitomycine_C.
- Mitomycin sameAs Mitomicina.
- Mitomycin sameAs マイトマイシンC.
- Mitomycin sameAs 미토마이신.
- Mitomycin sameAs Mitomycyna.
- Mitomycin sameAs m.08fr6v.
- Mitomycin sameAs Q417625.
- Mitomycin sameAs Q417625.
- Mitomycin sameAs DB00305.
- Mitomycin sameAs 5746.
- Mitomycin wasDerivedFrom Mitomycin?oldid=604820077.
- Mitomycin depiction Mitomycin.svg.
- Mitomycin isPrimaryTopicOf Mitomycin.
