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Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Muramyl_ligase> ?p ?o. }

• Muramyl_ligase abstract "The bacterial cell wall provides strength and rigidity to counteract internal osmotic pressure, and protection against the environment. The peptidoglycan layer gives the cell wall its strength, and helps maintain the overall shape of the cell. The basic peptidoglycan structure of both Gram-positive and Gram-negative bacteria comprises a sheet of glycan chains connected by short cross-linking polypeptides. Biosynthesis of peptidoglycan is a multi-step (11-12 steps) process comprising three main stages:(1) formation of UDP-N-acetylmuramic acid (UDPMurNAc) from N-acetylglucosamine (GlcNAc). (2) addition of a short polypeptide chain to the UDPMurNAc. (3) addition of a second GlcNAc to the disaccharide-pentapeptide building block and transport of this unit through the cytoplasmic membrane and incorporation into the growing peptidoglycan layer. Stage two involves four key Mur ubiquitin ligase enzymes: MurC (EC), MurD (EC), MurE (EC) and MurF (EC). These four Mur ligases are responsible for the successive additions of L-alanine, D-glutamate, meso-diaminopimelate or L-lysine, and D-alanyl-D-alanine to UDP-N-acetylmuramic acid. All four Mur ligases are topologically similar to one another, even though they display low sequence identity. They are each composed of three domains: an N-terminal Rossmann-fold domain responsible for binding the UDPMurNAc substrate; a central domain (similar to ATP-binding domains of several ATPases and GTPases); and a C-terminal domain (similar to dihydrofolate reductase fold) that appears to be associated with binding the incoming amino acid. The conserved sequence motifs found in the four Mur enzymes also map to other members of the Mur ligase family, including folylpolyglutamate synthetase, cyanophycin synthetase and the capB enzyme from Bacillales.This family includes UDP-N-acetylmuramate-L-alanine ligase (MurC), UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase (MurE), and UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (MurF). This entry also includes folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate and cyanophycin synthetase that catalyses the biosynthesis of the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartate (cyanophycin).".
• Muramyl_ligase symbol "Mur_ligase".
• Muramyl_ligase wikiPageExternalLink 6.3.2.10.
• Muramyl_ligase wikiPageExternalLink 6.3.2.13.
• Muramyl_ligase wikiPageExternalLink 6.3.2.8.
• Muramyl_ligase wikiPageExternalLink 6.3.2.9.
• Muramyl_ligase wikiPageID "35666184".
• Muramyl_ligase wikiPageRevisionID "592600878".
• Muramyl_ligase hasPhotoCollection Muramyl_ligase.
• Muramyl_ligase interpro "IPR000713".
• Muramyl_ligase name "Mur_ligase".
• Muramyl_ligase opmFamily "415".
• Muramyl_ligase opmProtein "1".
• Muramyl_ligase pfam "PF01225".
• Muramyl_ligase pfamClan "CL0063".
• Muramyl_ligase prosite "PDOC00773".
• Muramyl_ligase scop "1".
• Muramyl_ligase symbol "Mur_ligase".
• Muramyl_ligase subject Category:EC_6.3.2.
• Muramyl_ligase subject Category:Enzymes_of_known_structure.
• Muramyl_ligase subject Category:Protein_domains.
• Muramyl_ligase type Abstraction100002137.
• Muramyl_ligase type Activator114723079.
• Muramyl_ligase type Attribute100024264.
• Muramyl_ligase type Catalyst114723628.
• Muramyl_ligase type Chemical114806838.
• Muramyl_ligase type Compound114818238.
• Muramyl_ligase type Environment113934596.
• Muramyl_ligase type Enzyme114732946.
• Muramyl_ligase type EnzymesOfKnownStructure.
• Muramyl_ligase type Macromolecule114944888.
• Muramyl_ligase type Material114580897.
• Muramyl_ligase type Matter100020827.
• Muramyl_ligase type Molecule114682133.
• Muramyl_ligase type OrganicCompound114727670.
• Muramyl_ligase type Part113809207.
• Muramyl_ligase type PhysicalEntity100001930.
• Muramyl_ligase type Protein114728724.
• Muramyl_ligase type ProteinDomains.
• Muramyl_ligase type Relation100031921.
• Muramyl_ligase type Situation113927383.
• Muramyl_ligase type Sphere114514039.
• Muramyl_ligase type State100024720.
• Muramyl_ligase type Substance100019613.
• Muramyl_ligase type Thing100002452.
• Muramyl_ligase type Unit109465459.
• Muramyl_ligase type Biomolecule.
• Muramyl_ligase type Protein.
• Muramyl_ligase type BiologicalObject.
• Muramyl_ligase comment "The bacterial cell wall provides strength and rigidity to counteract internal osmotic pressure, and protection against the environment. The peptidoglycan layer gives the cell wall its strength, and helps maintain the overall shape of the cell. The basic peptidoglycan structure of both Gram-positive and Gram-negative bacteria comprises a sheet of glycan chains connected by short cross-linking polypeptides.".
• Muramyl_ligase label "Muramyl ligase".
• Muramyl_ligase sameAs m.0jk_bzl.
• Muramyl_ligase sameAs Q6937310.
• Muramyl_ligase sameAs Q6937310.
• Muramyl_ligase sameAs Muramyl_ligase.
• Muramyl_ligase wasDerivedFrom Muramyl_ligase?oldid=592600878.
• Muramyl_ligase isPrimaryTopicOf Muramyl_ligase.